Opioid receptor and peptide gene polymorphisms: potential implications for addictions

被引:115
作者
LaForge, KS [1 ]
Yuferov, V [1 ]
Kreek, MJ [1 ]
机构
[1] Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10021 USA
关键词
opioid system; endogenous; gene polymorphism; single nucleotide polymorphism; addiction; pharmacogenetics; physiogenetics;
D O I
10.1016/S0014-2999(00)00819-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Addictions to drugs of abuse and alcohol have been shown by studies of genetic epidemiology to have both a heritable and an environmental basis, with these factors influencing addiction to different substances to a different extent. In the search for specific alleles of specific genes that may contribute to the development of the addictions, many researchers have focused on the endogenous opioid system, which mediates a diverse array of neurological, physiological. and behavioral functions. The endogenous opioid system is also centrally important in mediating the effects of drugs of abuse and alcohol. Polymorphisms, including single nucleotide polymorphisms, have been identified in genes of the endogenous opioid receptors and peptides. A number of recent genetic association studies and a few studies of potential function provide clues as to which genes and which alleles may have implications for human physiology and pathophysiology, including the addictions. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:249 / 268
页数:20
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