Dynamic behaviour and stabilisation to boost the immune system by complex interaction between tumour cells and vitamins intervention

被引:10
作者
Alharbi, Sana Abdulkream [1 ,2 ]
Rambely, Azmin Sham [2 ]
机构
[1] Taibah Univ, Coll Sci, Dept Math & Stat, Yanbu 41911, Almadinah Almun, Saudi Arabia
[2] Univ Kebangsaan Malaysia, Fac Sci & Technol, Dept Math Sci, Bangi 43600, Selangor, Malaysia
关键词
Dynamic model; Nonlinear ordinary differential equations; Stability; Numerical simulation; Immune cells; Tumour cells; Vitamins; MATHEMATICAL-MODEL; CANCER; RISK; OBESITY;
D O I
10.1186/s13662-020-02869-6
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
In this paper, we establish and examine a mathematical model that combines the effects of vitamins intervention on strengthening the immune system and its role in suppressing and delaying the growth and division of tumour cells. In order to accomplish this, we propose a tumour-immune-vitamins model (TIVM) governed by ordinary differential equations and comprised of two populations, namely tumour and immune cells. It is presumed that the source of vitamins in TIVM originates from organic foods and beverages, based on the food pyramid. The simulation of TIVM employs the fourth order Runge-Kutta method. It is found from the analysis and simulation results that one of the side effects of weakening the immune system is the possibility of transforming immune cells into immune cancer cells to prevent or delay the growth and division of tumour cells. Evidently, for regular intakes of vitamins, which is projected at 55% of vitamins per day, the immune system is strengthened, preventing the production of tumour cells.
引用
收藏
页数:18
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共 30 条
  • [11] Development of the anti-cancer food scoring system 2.0: Validation and nutritional analyses of quantitative anti-cancer food scoring model
    Hong, Yeo-Jin
    Kim, Jeongseon
    Lee, Hye Yoon
    Rim, Chai Hong
    [J]. NUTRITION RESEARCH AND PRACTICE, 2020, 14 (01) : 32 - 44
  • [12] Jafari D., 2019, NUTR IMMUNITY
  • [13] The influence of time delay in a chaotic cancer model
    Khajanchi, Subhas
    Perc, Matjaz
    Ghosh, Dibakar
    [J]. CHAOS, 2018, 28 (10)
  • [14] Khan H., 2019, J. Crit. Rev, V7, P289
  • [15] Modeling immunotherapy of the tumor-immune interaction
    Kirschner, D
    Panetta, JC
    [J]. JOURNAL OF MATHEMATICAL BIOLOGY, 1998, 37 (03) : 235 - 252
  • [16] Effects of the obesity on optimal control schedules of chemotherapy on a cancerous tumor
    Ku-Carrillo, Roberto A.
    Delgadillo-Aleman, Sandra E.
    Chen-Charpentier, Benito M.
    [J]. JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS, 2017, 309 : 603 - 610
  • [17] A mathematical model for the effect of obesity on cancer growth and on the immune system response
    Ku-Carrillo, Roberto A.
    Delgadillo, Sandra E.
    Chen-Charpentier, B. M.
    [J]. APPLIED MATHEMATICAL MODELLING, 2016, 40 (7-8) : 4908 - 4920
  • [18] KUZNETSOV VA, 1994, B MATH BIOL, V56, P295, DOI 10.1007/BF02460644
  • [19] Western-style diet induces insulin insensitivity and hyperactivity in adolescent male rats
    Marwitz, Shannon E.
    Woodie, Lauren N.
    Blythe, Sarah N.
    [J]. PHYSIOLOGY & BEHAVIOR, 2015, 151 : 147 - 154
  • [20] A BASIC MATHEMATICAL-MODEL OF THE IMMUNE-RESPONSE
    MAYER, H
    ZAENKER, KS
    HEIDEN, UAD
    [J]. CHAOS, 1995, 5 (01) : 155 - 161