Terpenoids from the Octocorals Menella sp (Plexauridae) and Lobophytum crassum (Alcyonacea)

被引：24
作者：
Lee, Cheng-Hung [3 ,4 ,5 ]
Kao, Chia-Ying [6 ,7 ,8 ,9 ]
Kao, Shih-Yao [6 ,7 ,8 ,9 ]
Chang, Chih-Han [3 ]
Su, Jui-Hsin [1 ,2 ,6 ,7 ,8 ,9 ]
Hwang, Tsong-Long [10 ]
Kuo, Yueh-Hsiung [11 ,12 ]
Wen, Zhi-Hong [1 ,2 ]
Sung, Ping-Jyun [1 ,2 ,6 ,7 ,8 ,9 ]
机构：
[1] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
[2] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Div Marine Biotechnol, Kaohsiung 804, Taiwan
[3] Natl Cheng Kung Univ, Dept Biomed Engn, Tainan 701, Taiwan
[4] HungKuang Univ, Dept Nutr, Taichung 433, Taiwan
[5] Taichung Vet Gen Hosp, Dept Orthoped, Taichung 407, Taiwan
[6] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan
[7] Natl Dong Hwa Univ, Dept Life Sci, Pingtung 944, Taiwan
[8] Natl Dong Hwa Univ, Inst Biotechnol, Pingtung 944, Taiwan
[9] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan
[10] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan
[11] China Med Univ, Sch Chinese Pharmaceut Sci & Chinese Med Resource, Coll Pharm, Taichung 404, Taiwan
[12] China Med Univ, Tsuzuki Inst Tradit Med, Coll Pharm, Taichung 404, Taiwan
来源：
MARINE DRUGS | 2012年 / 10卷 / 02期
关键词：
menelloide; germacrane; Menella; lobocrassin; cembrane; Lobophytum; elastase; OXYGENATED GUAIANE LACTONES; ANTIINFLAMMATORY CEMBRANOIDS; BIOACTIVE CEMBRANOIDS; VERRUCOSA BRUNDIN; CORAL; SESQUITERPENOIDS; DITERPENES;
D O I：
10.3390/md10020427
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils.
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页码：427 / 438
页数：12
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