Antimitochondrial antibody-negative primary biliary cirrhosis

被引:26
作者
Mendes, Flavia [2 ]
Lindor, Keith D. [1 ]
机构
[1] Mayo Clin Coll Med, Mayo Med Sch, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
[2] Univ Miami, Miller Sch Med, Div Hepatol, Miami, FL 33136 USA
关键词
D O I
10.1016/j.gtc.2008.02.006
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
There is a subset of patients who have biochemical and histologic features consistent with primary biliary cirrhosis (PBC) who lack antimitochondrial antibodies (AMA). This entity is usually referred to as AMA-negative PBC or alternatively autoimmune cholangitis. Patients who have AMA-negative PBC are believed to have a similar clinical course, response to treatment, and prognosis as their AMA-positive counterparts. As more sensitive and specific serologic tests are developed to detect serum AMA, it is possible we may find that these patients initially believed to be AMA-negative are indeed AMA-positive, suggesting a single disease process.
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页码:479 / +
页数:7
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