Oxytocin-mediated social enrichment promotes loner telomeres and novelty seeking

被引：34

作者：

Faraji, Jamshid ^{[1
,2
]}

Karimi, Mitra ^{[3
]}

Soltanpour, Nabiollah ^{[4
]}

Moharrerie, Alireza ^{[5
]}

Rouhzadeh, Zahra ^{[6
]}

Lotfi, Hamid ^{[7
]}

Hosseini, S. Abedin ^{[2
]}

Jafari, S. Yaghoob ^{[2
]}

Roudaki, Shabnam ^{[8
]}

Moeeini, Reza ^{[8
]}

Metz, Gerlinde A. S. ^{[1
]}

机构：

[1] Univ Lethbridge, Canadian Ctr Behav Neurosci, Lethbridge, AB, Canada

[2] Golestan Univ Med Sci, Fac Nursing & Midwifery, Gorgan, Iran

[3] Except Educ Org, Inclus Integrated Educ Program Children Special N, Tehran, Iran

[4] Babol Univ Med Sci, Dept Anat Sci, Babol Sar, Iran

[5] Golestan Univ Med Sci, Dept Anat, Gorgan, Iran

[6] Islamic Azad Univ, Dept Psychol, Sari, Iran

[7] Islamic Azad Univ, Dept Psychol, Tonekabon, Iran

[8] Avicenna Inst Neurosci, Dept Behav Studies, Yazd, Iran

来源：

ELIFE | 2018年 / 7卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

SEX-DIFFERENCES; NEURAL CIRCUITRY; STRESS; LENGTH; RECEPTOR; BEHAVIOR; HEALTH; RATS; VASOPRESSIN; EXPERIENCE;

D O I：

10.7554/eLife.40262

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The quality of social relationships is a powerful determinant of lifetime health. Here, we explored the impact of social experiences on circulating oxytocin (OT) concentration, telomere length (TL), and novelty-seeking behaviour in male and female rats. Prolonged social housing raised circulating OT levels in both sexes while elongating TL only in females. Novelty-seeking behaviour in females was more responsive to social housing and increased OT levels than males. The OT antagonist (OT ANT) L-366,509 blocked the benefits of social housing in all conditions along with female-specific TL erosion and novelty-seeking deficit. Thus, females seem more susceptible than males to genetic and behavioural changes when the secretion of endogenous OT in response to social life is interrupted. Social enrichment may, therefore, provide a therapeutic avenue to promote stress resiliency and chances of healthy aging across generations.

引用

页数：18

共 93 条

[1] Responses of the extrapyramidal and limbic substance P systems to ibogaine and cocaine treatments [J].