Ruthenium-Catalyzed Para-Selective Oxidative Cross-Coupling of Arenes and Cycloalkanes

被引：105
作者：
Guo, Xiangyu [1 ]
Li, Chao-Jun [1 ]
机构：
[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 19期
基金：
加拿大自然科学与工程研究理事会;
关键词：
C-H FUNCTIONALIZATION; NITROGEN-HETEROCYCLES; ARYLATION; METALATION; OLEFINS; ACIDS;
D O I：
10.1021/ol202081c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel, direct para-selective oxidative cross-coupling of benzene derivatives with cycloalkanes catalyzed by ruthenium was developed. A wide range of arenes bearing electron-withdrawing substituents was functionalized directly with simple cycloalkanes with high para-selectivity; arenes with electron-donating groups were mainly para-functionalized. Benzoic acid can be used directly.
引用
收藏
页码：4977 / 4979
页数：3
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