The Complex Interplay between Lipids, Immune System and Interleukins in Cardio-Metabolic Diseases

被引：52

作者：

Bernardi, Stella ^{[1
]}

Marcuzzi, Annalisa ^{[2
]}

Piscianz, Elisa ^{[2
]}

Tommasini, Alberto ^{[3
]}

Fabris, Bruno ^{[1
]}

机构：

[1] Univ Trieste, Cattinara Teaching Hosp, Dept Med Surg & Hlth Sci, I-34149 Trieste, Italy

[2] Univ Trieste, Dept Med Surg & Hlth Sci, I-34149 Trieste, Italy

[3] Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Dept Pediat, I-34137 Trieste, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 12期

关键词：

lipid; innate immune system; interleukin; lipotoxicity; cholesterol; triglyceride; free fatty acids; TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; TOLL-LIKE RECEPTORS; INDUCED INSULIN-RESISTANCE; UNSATURATED FATTY-ACIDS; LOW-DENSITY-LIPOPROTEIN; ADIPOSE-TISSUE INFLAMMATION; OF-FUNCTION MUTATION; SMOOTH-MUSCLE-CELLS;

D O I：

10.3390/ijms19124058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipids and inflammation regulate each other. Early studies on this topic focused on the systemic effects that the acute inflammatory responseand interleukinshad on lipid metabolism. Today, in the era of the obesity epidemic, whose primary complications are cardio-metabolic diseases, attention has moved to the effects that the nutritional environment and lipid derangements have on peripheral tissues, where lipotoxicity leads to organ damage through an imbalance of chronic inflammatory responses. After an overview of the effects that acute inflammation has on the systemic lipid metabolism, this review will describe the lipid-induced immune responses that take place in peripheral tissues and lead to chronic cardio-metabolic diseases. Moreover, the anti-inflammatory effects of lipid lowering drugs, as well as the possibility of using anti-inflammatory agents against cardio-metabolic diseases, will be discussed.

引用

页数：24

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