Retrospective comparison of nab-paclitaxel plus ramucirumab and paclitaxel plus ramucirumab as second-line treatment for advanced gastric cancer focusing on peritoneal metastasis

被引：20

作者：

Ishikawa, Masashi ^{[1
,2
]}

Iwasa, Satoru ^{[1
]}

Nagashima, Kengo ^{[3
,4
]}

Aoki, Masahiko ^{[1
]}

Imazeki, Hiroshi ^{[1
]}

Hirano, Hidekazu ^{[1
]}

Shoji, Hirokazu ^{[1
]}

Honma, Yoshitaka ^{[1
]}

Okita, Natsuko ^{[1
]}

Takashima, Atsuo ^{[1
]}

Kato, Ken ^{[1
]}

Saruta, Masayuki ^{[2
]}

Boku, Narikazu ^{[1
]}

机构：

[1] Natl Canc Ctr, Gastrointestinal Med Oncol Div, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan

[2] Jikei Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Sch Med,Minato Ku, 3-19-18 Nishishinbashi, Tokyo 1058471, Japan

[3] Res Ctr Med & Hlth Data Sci, Inst Stat Math, 10-3 Midori Cho, Tachikawa, Tokyo 1908562, Japan

[4] Keio Univ, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1600016, Japan

来源：

INVESTIGATIONAL NEW DRUGS | 2020年 / 38卷 / 02期

关键词：

Nab-paclitaxel; Gastric cancer; Peritoneal metastasis; Ramucirumab; RAINBOW; GP60;

D O I：

10.1007/s10637-019-00822-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Ramucirumab (RAM) plus solvent-based (sb)-paclitaxel (PTX) is the standard second-line chemotherapy for advanced gastric cancer (AGC). The subset analysis of the ABSOLUTE trial, which confirmed non-inferiority of weekly nanoparticle albumin-bound (nab)-PTX to weekly sb-PTX, suggested that nab-PTX might have better efficacy than sb-PTX in patients with peritoneal metastasis. We retrospectively evaluated the efficacy and safety of RAM plus sb-PTX and nab-PTX in patients with peritoneal metastasis of AGC. Methods AGC patients who received RAM plus sb-PTX or nab-PTX as second-line chemotherapy from June 2015 to February 2019 were included in the study. Overall survival (OS), progression-free survival (PFS), response rate, and safety were assessed. Results A total of 128 patients were included in this study (93 in the RAM plus sb-PTX group and 35 in the RAM plus nab-PTX group). PFS was 4.1 months in the RAM plus sb-PTX group and 4.6 months in the RAM plus nab-PTX group (HR 0.90; 95%CI 0.58-1.41, p = 0.643). OS was 8.9 months in the RAM plus sb-PTX group and 11.4 months in the RAM plus nab-PTX group (HR 0.95; 95%CI 0.56-1.62, p = 0.847). A total of 62 and 31 patients had peritoneal metastasis in the RAM plus sb-PTX and the RAM plus nab-PTX groups, respectively. RAM plus nab-PTX showed a slightly longer survival compared to RAM plus sb-PTX in patients with peritoneal metastasis (PFS 5.8 vs 3.5 months, HR 0.66; 95% CI 0.40-1.10, p = 0.109). Conclusion This study suggests that RAM plus nab-PTX might be a more effective treatment for peritoneal metastasis of AGC.

引用

页码：533 / 540

页数：8

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