EGFR mutations in lung cancer: from tissue testing to liquid biopsy

被引：75

作者：

Fenizia, Francesca ^{[1
]}

De Luca, Antonella ^{[2
]}

Pasquale, Raffaella ^{[1
]}

Sacco, Alessandra ^{[1
]}

Forgione, Laura ^{[1
]}

Lambiase, Matilde ^{[1
]}

Iannaccone, Alessia ^{[1
]}

Chicchinelli, Nicoletta ^{[2
]}

Franco, Renato ^{[3
]}

Rossi, Antonio ^{[4
]}

Morabito, Alessandro ^{[5
]}

Rocco, Gaetano ^{[6
]}

Piccirillo, Maria Carmela ^{[7
]}

Normanno, Nicola ^{[1
,2
]}

机构：

[1] Ist Nazl Tumori Fdn G Pascale IRCCS, CROM, Lab Pharmacogen, Mercogliano, AV, Italy

[2] Ist Nazl Tumori Fdn G Pascale IRCCS, Cell Biol & Biotherapy Unit, Naples, Italy

[3] Ist Nazl Tumori Fdn G Pascale IRCCS, Surg Pathol Unit, Naples, Italy

[4] SG Moscati Hosp, Div Med Oncol, Avellino, Italy

[5] Ist Nazl Tumori Fdn G Pascale IRCCS, Med Oncol Unit, Thoracopulm Dept, Naples, Italy

[6] Ist Nazl Tumori Fdn G Pascale IRCCS, Thorac Surg, Thoracopulm Dept, Naples, Italy

[7] Ist Nazl Tumori Fdn G Pascale IRCCS, Clin Trials Unit, Naples, Italy

来源：

FUTURE ONCOLOGY | 2015年 / 11卷 / 11期

关键词：

EGFR mutations; EGFR-TKIs; liquid biopsy; mechanisms of resistance; non-small-cell lung carcinoma; targeted therapy; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; CIRCULATING TUMOR DNA; ACQUIRED-RESISTANCE; OPEN-LABEL; PHASE-III; 1ST-LINE TREATMENT; GEFITINIB TREATMENT; MET AMPLIFICATION; DRUG-RESISTANCE;

D O I：

10.2217/fon.15.23

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The presence of EGFR mutations predicts the sensitivity to EGF receptor (EGFR)-tyrosine kinase inhibitors in a molecularly defined subset of non-small-cell lung carcinoma (NSCLC) patients. For this reason, EGFR testing of NSCLC is required to provide personalized treatment options and better outcomes for NSCLC patients. As surgery specimens are not available in the majority of NSCLC, other currently available DNA sources are small biopsies and cytological samples, providing however limited and low-quality material. In order to address this issue, the use of surrogate sources of DNA, such as blood, serum and plasma samples, which often contains circulating free tumor DNA or circulating tumor cells, is emerging as a new strategy for tumor genotyping.

引用

页码：1611 / 1623

页数：13

共 75 条

[1]

[Anonymous], J CLIN ONCOL S5

[2]

[Anonymous], J CLIN ONCOL S5

[3]

[Anonymous], J CLIN ONCOL S5

[4] Detection and Clinical Significance of Intratumoral EGFR Mutational Heterogeneity in Chinese Patients with Advanced Non-Small Cell Lung Cancer [J].

Bai, Hua ;

Wang, Zhijie ;

Wang, Yuyan ;

Zhuo, Minglei ;

Zhou, Qinghua ;

Duan, Jianchun ;

Yang, Lu ;

Wu, Meina ;

An, Tongtong ;

Zhao, Jun ;

Wang, Jie .

PLOS ONE, 2013, 8 (02)

[5] Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies [J].

Bettegowda, Chetan ;

Sausen, Mark ;

Leary, Rebecca J. ;

Kinde, Isaac ;

Wang, Yuxuan ;

Agrawal, Nishant ;

Bartlett, Bjarne R. ;

Wang, Hao ;

Luber, Brandon ;

Alani, Rhoda M. ;

Antonarakis, Emmanuel S. ;

Azad, Nilofer S. ;

Bardelli, Alberto ;

Brem, Henry ;

Cameron, John L. ;

Lee, Clarence C. ;

Fecher, Leslie A. ;

Gallia, Gary L. ;

Gibbs, Peter ;

Le, Dung ;

Giuntoli, Robert L. ;

Goggins, Michael ;

Hogarty, Michael D. ;

Holdhoff, Matthias ;

Hong, Seung-Mo ;

Jiao, Yuchen ;

Juhl, Hartmut H. ;

Kim, Jenny J. ;

Siravegna, Giulia ;

Laheru, Daniel A. ;

Lauricella, Calogero ;

Lim, Michael ;

Lipson, Evan J. ;

Marie, Suely Kazue Nagahashi ;

Netto, George J. ;

Oliner, Kelly S. ;

Olivi, Alessandro ;

Olsson, Louise ;

Riggins, Gregory J. ;

Sartore-Bianchi, Andrea ;

Schmidt, Kerstin ;

Shih, Ie-Ming ;

Oba-Shinjo, Sueli Mieko ;

Siena, Salvatore ;

Theodorescu, Dan ;

Tie, Jeanne ;

Harkins, Timothy T. ;

Veronese, Silvio ;

Wang, Tian-Li ;

Weingart, Jon D. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

[6] FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR [J].

Bivona, Trever G. ;

Hieronymus, Haley ;

Parker, Joel ;

Chang, Kenneth ;

Taron, Miquel ;

Rosell, Rafael ;

Moonsamy, Philicia ;

Dahlman, Kimberly ;

Miller, Vincent A. ;

Costa, Carlota ;

Hannon, Gregory ;

Sawyers, Charles L. .

NATURE, 2011, 471 (7339) :523-526

[7] Non-small-cell lung cancers: a heterogeneous set of diseases [J].

Chen, Zhao ;

Fillmore, Christine M. ;

Hammerman, Peter S. ;

Kim, Carla F. ;

Wong, Kwok-Kin .

NATURE REVIEWS CANCER, 2014, 14 (08) :535-546

[8] Molecular mechanisms of resistance in epidermal growth factor receptor-mutant lung adenocarcinomas [J].

Cortot, Alexis B. ;

Jaenne, Pasi A. .

EUROPEAN RESPIRATORY REVIEW, 2014, 23 (133) :356-366

[9] The Impact of EGFR T790M Mutations and BIM mRNA Expression on Outcome in Patients with EGFR-Mutant NSCLC Treated with Erlotinib or Chemotherapy in the Randomized Phase III EURTAC Trial [J].

Costa, Carlota ;

Molina, Miguel Angel ;

Drozdowskyj, Ana ;

Gimenez-Capitan, Ana ;

Bertran-Alamillo, Jordi ;

Karachaliou, Niki ;

Gervais, Radj ;

Massuti, Bartomeu ;

Wei, Jia ;

Moran, Teresa ;

Majem, Margarita ;

Felip, Enriqueta ;

Carcereny, Enric ;

Garcia-Campelo, Rosario ;

Viteri, Santiago ;

Taron, Miquel ;

Ono, Mayumi ;

Giannikopoulos, Petros ;

Bivona, Trever ;

Rosell, Rafael .

CLINICAL CANCER RESEARCH, 2014, 20 (07) :2001-2010

[10] Predictive Biomarkers to Tyrosine Kinase Inhibitors for the Epidermal Growth Factor Receptor in Non-Small-Cell Lung Cancer [J].

De Luca, A. ;

Normanno, N. .

CURRENT DRUG TARGETS, 2010, 11 (07) :851-864

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