Identification, Validation, and Application of Molecular Diagnostics for Insecticide Resistance in Malaria Vectors

被引：85
作者：
Donnelly, Martin J. [1 ,2 ]
Isaacs, Alison T. [1 ]
Weetman, David [1 ]
机构：
[1] Univ Liverpool Liverpool Sch Trop Med, Dept Vector Biol, Pembroke Pl, Liverpool L3 5QA, Merseyside, England
[2] Wellcome Trust Sanger Inst, Malaria Programme, Cambridge, England
来源：
TRENDS IN PARASITOLOGY | 2016年 / 32卷 / 03期
关键词：
ANOPHELES-GAMBIAE S.S; PYRETHROID RESISTANCE; SODIUM-CHANNEL; MUTATION; FUNESTUS; EXPRESSION; GENES; GHANA; KDR; POPULATIONS;
D O I：
10.1016/j.pt.2015.12.001
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Insecticide resistance is a major obstacle to control of Anopheles malaria mosquitoes in sub-Saharan Africa and requires an improved understanding of the underlying mechanisms. Efforts to discover resistance genes and DNA markers have been dominated by candidate gene and quantitative trait locus studies of laboratory strains, but with greater availability of genome sequences a shift toward field-based agnostic discovery is anticipated. Mechanisms evolve continually to produce elevated resistance yielding multiplicative diagnostic markers, co-screening of which can give high predictive value. With a shift toward prospective analyses, identification and screening of resistance marker panels will boost monitoring and programmatic decision making.
引用
收藏
页码：197 / 206
页数：10
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