Identification, Validation, and Application of Molecular Diagnostics for Insecticide Resistance in Malaria Vectors

被引：85

作者：

Donnelly, Martin J. ^{[1
,2
]}

Isaacs, Alison T. ^{[1
]}

Weetman, David ^{[1
]}

机构：

[1] Univ Liverpool Liverpool Sch Trop Med, Dept Vector Biol, Pembroke Pl, Liverpool L3 5QA, Merseyside, England

[2] Wellcome Trust Sanger Inst, Malaria Programme, Cambridge, England

来源：

TRENDS IN PARASITOLOGY | 2016年 / 32卷 / 03期

关键词：

ANOPHELES-GAMBIAE S.S; PYRETHROID RESISTANCE; SODIUM-CHANNEL; MUTATION; FUNESTUS; EXPRESSION; GENES; GHANA; KDR; POPULATIONS;

D O I：

10.1016/j.pt.2015.12.001

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Insecticide resistance is a major obstacle to control of Anopheles malaria mosquitoes in sub-Saharan Africa and requires an improved understanding of the underlying mechanisms. Efforts to discover resistance genes and DNA markers have been dominated by candidate gene and quantitative trait locus studies of laboratory strains, but with greater availability of genome sequences a shift toward field-based agnostic discovery is anticipated. Mechanisms evolve continually to produce elevated resistance yielding multiplicative diagnostic markers, co-screening of which can give high predictive value. With a shift toward prospective analyses, identification and screening of resistance marker panels will boost monitoring and programmatic decision making.

引用

页码：197 / 206

页数：10

共 71 条

[1] Impacts of Agricultural Practices on Insecticide Resistance in the Malaria Vector Anopheles arabiensis in Khartoum State, Sudan [J].

Abuelmaali, Sara A. ;

Elaagip, Arwa H. ;

Basheer, Mohammed A. ;

Frah, Ehab A. ;

Ahmed, Fayez T. A. ;

Elhaj, Hassabelrasoul F. A. ;

Seidahmed, Osama M. E. ;

Weetman, David ;

Hamid, Muzamil Mahdi Abdel .

PLOS ONE, 2013, 8 (11)

[2]

Abut H., 2008, CHEM BIOL INTERACT, V175, P133

[3] Insecticide Resistance Alleles Affect Vector Competence of Anopheles gambiae s.s. for Plasmodium falciparum Field Isolates [J].

Alout, Haoues ;

Ndam, Nicaise Tuikue ;

Sandeu, Marcel Maurice ;

Djegbe, Innocent ;

Chandre, Fabrice ;

Dabire, Roch Kounbobr ;

Djogbenou, Luc Salako ;

Corbel, Vincent ;

Cohuet, Anna .

PLOS ONE, 2013, 8 (05)

[4] Over expression of a cytochrome p450 (CYP6P9) in a major African malaria vector, Anopheles funestus, resistant to pyrethroids [J].

Amenya, D. A. ;

Naguran, R. ;

Lo, T. -C. M. ;

Ranson, H. ;

Spillings, B. L. ;

Wood, O. R. ;

Brooke, B. D. ;

Coetzee, M. ;

Koekemoer, L. L. .

INSECT MOLECULAR BIOLOGY, 2008, 17 (01) :19-25

[5] Detection of knockdown resistance (kdr) mutations in Anopheles gambiae:: a comparison of two new high-throughput assays with existing methods [J].

Bass, Chris ;

Nikou, Dimitra ;

Donnelly, Martin J. ;

Williamson, Martin S. ;

Ranson, Hilary ;

Ball, Amanda ;

Vontas, John ;

Field, Linda M. .

MALARIA JOURNAL, 2007, 6 (1)

[6] The Anopheles gambiae detoxification chip:: A highly specific microarray to study metabolic-based insecticide resistance in malaria vectors [J].

David, JP ;

Strode, C ;

Vontas, J ;

Nikou, D ;

Vaughan, A ;

Pignatelli, PM ;

Louis, C ;

Hemingway, J ;

Ranson, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (11) :4080-4084

[7] A comparative study of voltage-gated sodium channels in the Insecta: implications for pyrethroid resistance in anopheline and other neopteran species [J].

Davies, T. G. E. ;

Field, L. M. ;

Usherwood, P. N. R. ;

Williamson, M. S. .

INSECT MOLECULAR BIOLOGY, 2007, 16 (03) :361-375

[8] Evolutionary genetics - Insecticide resistance on the move [J].

Denholm, I ;

Devine, GJ ;

Williamson, MS .

SCIENCE, 2002, 297 (5590) :2222-2223

[9] The Anopheles gambiae glutathione transferase supergene family:: annotation, phylogeny and expression profiles -: art. no. 35 [J].

Ding, YC ;

Ortelli, F ;

Rossiter, LC ;

Hemingway, J ;

Ranson, H .

BMC GENOMICS, 2003, 4 (1)

[10] Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector Anopheles gambiae homozygous for the G119S mutation [J].

Djogbenou, Luc ;

Noel, Valerie ;

Agnew, Philip .

MALARIA JOURNAL, 2010, 9

← 1 2 3 4 5 6 7 8 →