Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin

被引：29

作者：

Yao, Meng-Zhu ^{[1
]}

Huang-Fu, Ming-Yi ^{[1
]}

Liu, Hui-Na ^{[1
]}

Wang, Xia-Rong ^{[1
]}

Sheng, Xiaoxia ^{[2
]}

Gao, Jian-Qing ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmaceut, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

[2] Hangzhou SoliPharma Co Ltd, Hangzhou, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2016年 / 11卷

关键词：

BMSCs; tissue engineering; porous scaffold; carbon nanotubes; silk fibroin; surface modification; dexamethasone; PROGENITOR CELLS; BONE; DELIVERY; STEM; MICROSPHERES; BIOMATERIALS; RELEASE;

D O I：

10.2147/IJN.S106929

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Nano-hydroxyapatite/polyamide 66 (nHA/PA66) porous scaffolds were fabricated by a phase inversion method. Carbon nanotubes (CNTs) and silk fibroin (SF) were used to modify the surface of the nHA/PA66 scaffolds by freeze-drying and cross-linking. Dexamethasone was absorbed to the CNTs to promote the osteogenic differentiation of bone mesenchymal stem cells (BMSCs). The cell viability of BMSCs was investigated by changing the concentration of the CNT dispersion, and the most biocompatible scaffold was selected. In addition, the morphology and mechanical property of the scaffolds were investigated. The results showed that the nHA/PA66 scaffolds modified with CNTs and SF met the requirements of bone tissue engineering scaffolds. The dexamethasone-loaded CNT/SF-nHA/PA66 composite scaffold promoted the osteogenic differentiation of BMSCs, and the drug-loaded scaffolds are expected to function as effective bone tissue engineering scaffolds.

引用

页码：6181 / 6194

页数：14

共 53 条

[1] Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair [J].

Agarwal, Rachit ;

Garcia, Andres J. .

ADVANCED DRUG DELIVERY REVIEWS, 2015, 94 :53-62

[2] Protective role of functionalized single walled carbon nanotubes enhance ex vivo expansion of hematopoietic stem and progenitor cells in human umbilical cord blood [J].

Bari, Sudipto ;

Chu, Pat Pak Yan ;

Lim, Andrea ;

Fan, Xiubo ;

Gay, Florence Pik Hoon ;

Bunte, Ralph Milford ;

Lim, Tony Kiat Hon ;

Li, Shang ;

Chiu, Gigi Ngar Chee ;

Hwang, William Ying Khee .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2013, 9 (08) :1304-1316

[3]

Black Cameron R M, 2015, Curr Mol Biol Rep, V1, P132

[4] Commentary: Deciphering the link between architecture and biological response of a bone graft substitute [J].

Bohner, M. ;

Loosli, Y. ;

Baroud, G. ;

Lacroix, D. .

ACTA BIOMATERIALIA, 2011, 7 (02) :478-484

[5] Biomaterial developments for bone tissue engineering [J].

Burg, KJL ;

Porter, S ;

Kellam, JF .

BIOMATERIALS, 2000, 21 (23) :2347-2359

[6] Molecular basis of restenosis and drug-eluting stents [J].

Costa, MA ;

Simon, DI .

CIRCULATION, 2005, 111 (17) :2257-2273

[7] BONE TISSUE ENGINEERING [J].

CRANE, GM ;

ISHAUG, SL ;

MIKOS, AG .

NATURE MEDICINE, 1995, 1 (12) :1322-1324

[8]

Cypher T J, 1996, J Foot Ankle Surg, V35, P413

[9]

Fan Jianbo, 2012, Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, V29, P1119

[10] Diopside modified porous polyglycolide scaffolds with improved properties [J].

Feng, Pei ;

Guo, Xiaoning ;

Gao, Chengde ;

Gao, Dan ;

Xiao, Tao ;

Shuai, Xiong ;

Shuai, Cijun ;

Peng, Shuping .

RSC ADVANCES, 2015, 5 (68) :54822-54829

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