Insulin resistance in latent autoimmune diabetes of adulthood

被引：24
作者：
Behme, MT
Dupré, J
Harris, SB
Hramiak, IM
Mahon, JL
机构：
[1] Univ Western Ontario, Lawson Hlth Res Inst, London, ON N6A 3K7, Canada
[2] Univ Western Ontario, Robarts Res Inst, London, ON N6A 3K7, Canada
[3] Univ Western Ontario, London Hlth Sci Ctr, London, ON N6A 3K7, Canada
来源：
IMMUNOLOGY OF DIABETES II: PATHOGENESIS FROM MOUSE TO MAN | 2003年 / 1005卷
关键词：
latent autoimmune diabetes of adulthood (LADA); homeostasis model assessment (HOMA); insulin resistance;
D O I：
10.1196/annals.1288.062
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulin resistance in patients with latent autoimmune diabetes of adulthood (LADA) was determined by homeostasis model assessment (HOMA). LADA was identified by a clinical phenotype of type 2 diabetes with antibodies to GAD65 and/or IA-2/ICA512. All patients were managed with insulin therapy. Insulin resistance in LADA was lower than in antibody-negative type 2 diabetes, higher than in normal humans and in recent-onset type I diabetes, and similar to that in long-term type 1 diabetes. Mean values for HOMA varied linearly with mean values for BMI, which accounted for much of the insulin resistance in these forms of diabetes. LADA resembles long-term type I diabetes with respect to insulin resistance and BMI, but occurs at an older age.
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页码：374 / 377
页数：4
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