SYNTHESIS OF NEW 1,3-OXAZOLYL-7-CHLOROQUINAZOLIN-4(3H)ONES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITIES

被引：0
|
作者：
Patel, Navin B. [1 ]
Shaikh, Asif R. [1 ]
机构：
[1] Veer Nanriad S Gujarat Univ, Dept Chem, Surat 395007, India
来源：
ACTA POLONIAE PHARMACEUTICA | 2011年 / 68卷 / 02期
关键词：
antibacterial; antifungal; benzoxazinone; 1; 3-oxazole; quinazolinone; BIOLOGICAL EVALUATION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
2-[2-(2,6-Dichlorophenyl)amino]phenylmethyl-3-{4-[(substituted phenyl)amino]-1,3-oxazol-2-yl}-7-chloroquinazolin-4(3H)ones 5a-o have been prepared from 2-[(2,6-dichloro phenyl)amino]phenyl acetic acid 1, which was converted to acid chloride 2 and cyclized with anthranilic acid afforded benzoxazin-4(H)ones 3. Further reaction with urea gave carboxamide-7-chloroquinazolin-4(3H)ones 4 cyclized with substituted phenyl acetamide a-o. All the compounds have been confirmed by elemental analysis, IR, NMR spectral data and evaluated for antimicrobial activity. Compounds 5o, 5k, and 5m (R = 1-H, 2,5-(Cl)(2), and 2-Cl, 4-NO2) showed good activity, compared with the standard drugs.
引用
收藏
页码：223 / 230
页数：8
相关论文
共 50 条
  • [1] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW 1,3-THIAZOLYLQUINAZOLIN-4-(3H)-ONES
    Patel, N. B.
    Patel, J. N.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2009, 18 (03) : 247 - 250
  • [2] IN VITRO ANTIMICROBIAL STUDIES OF NEWLY SYNTHESIZED 1, 3-OXAZOLYL-QUINAZOLIN-4(3H) ONES
    Navin, Patel B.
    Asif, Shaikh R.
    FARMACIA, 2011, 59 (04) : 531 - 538
  • [3] SYNTHESIS AND IN VITRO ANTIMICROBIAL EVALUATION OF PYRAZOLYL-QUINAZOLIN-4(3H)-ONES
    Patel, Navin B.
    Shaikh, Asif R.
    Barat, Gaman G.
    ACTA POLONIAE PHARMACEUTICA, 2012, 69 (06): : 1067 - 1075
  • [4] Synthesis and antimicrobial evaluation of new halogenated 1,3-Thiazolidin-4-ones
    Hammad, Shaymaa G.
    El-Gazzar, Marwa G.
    Abutaleb, Nader S.
    Li, Daoyi
    Ramming, Isabell
    Shekhar, Aditya
    Abdel-Halim, Mohammad
    Elrazaz, Eman Z.
    Seleem, Mohamed N.
    Bilitewski, Ursula
    Abouzid, Khaled A. M.
    El-Hossary, Ebaa M.
    BIOORGANIC CHEMISTRY, 2020, 95
  • [5] Synthesis of some new quinazolin-4(3H)-ones as possible antimicrobial agents
    Mishra, P
    Jain, SK
    Jain, S
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1997, 74 (10) : 816 - 817
  • [6] Synthesis and biological activity of some new 1,3-thiazolyl-6-bromoquinazolin-4(3H)ones
    Patel, N. B.
    Patel, J. N.
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2009, 86 (11) : 1231 - 1236
  • [7] A New Approach to the Synthesis of Benzo[c][1,7] naphthyridin-4(3H)-ones
    Kulakov, Ivan V.
    Shatsauskas, Anton L.
    Matsukevich, Mariya V.
    Palamarchuk, Irina V.
    Seilkhanov, Tulegen M.
    Gatilov, Yuriy V.
    Fisyuk, Alexander S.
    SYNTHESIS-STUTTGART, 2017, 49 (16): : 3700 - 3709
  • [8] SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF NOVEL 2-(BENZO[D][1,3]DIOXOL-5-YL)-6,7-DIMETHOXYLQUINAZOLIN-4(3H)-ONES
    Kancharla, Suman
    BharathYarlagadda
    Murthy, Ch S. S. S.
    Devunuri, Nagaraju
    HETEROCYCLIC LETTERS, 2015, 5 (04): : 645 - 652
  • [9] Synthesis and Antimicrobial Activity of Novel 1,3,4-Oxadiazolyl-quinazolin-4(3H)ones
    Patel, Navin B.
    Patel, Jaymin C.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (04) : 923 - 931
  • [10] SYNTHESIS OF SOME SCHIFF-BASES OF 3-AMINO-2-METHYLQUINAZOLIN-4(3H)-ONES AND THEIR ANTIMICROBIAL ACTIVITIES
    MISHRA, P
    GUPTA, PN
    SHAKYA, AK
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1991, 68 (11) : 618 - 619
12345