Designed Synthesis of Natural DNA as a Main Chain-based Brush-shaped Copolymer

被引：1

作者：

Song, Yingying ^{[1
]}

Yao, Yanhuan ^{[1
]}

Jin, Susu ^{[1
]}

Tang, Yating ^{[1
]}

Huang, Yapeng ^{[1
]}

Chen, Haiyang ^{[1
]}

Wang, Ying ^{[1
]}

Mi, Huaifeng ^{[1
]}

机构：

[1] Nankai Univ, Inst Polymer Chem, Minist Educ, Key Lab Funct Polymer Mat, Tianjin 300071, Peoples R China

来源：

CHEMISTRY LETTERS | 2015年 / 44卷 / 06期

基金：

中国国家自然科学基金;

关键词：

O-H INSERTION; VINYL-POLYMERS; OLIGONUCLEOTIDES; HYBRIDIZATION; CHEMISTRY; ACID;

D O I：

10.1246/cl.150098

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A type of brush-shaped copolymer with natural DNA as the main chain is synthesized. Multiple alkyne groups are introduced onto the phosphate backbone of natural DNA via an O-H insertion reaction, thus rendering the DNA sequence reactive for the subsequent grafting with azide-terminated poly(ethylene glycol) (PEG-N-3) by click reaction. This is the first synthesis of natural DNA as a main chain brush-shaped copolymer. The resulting novel copolymer may have potential for electrochemical DNA biosensors and gene delivery.

引用

页码：740 / 742

页数：3

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