Designed Synthesis of Natural DNA as a Main Chain-based Brush-shaped Copolymer

被引：1
|
作者：
Song, Yingying [1 ]
Yao, Yanhuan [1 ]
Jin, Susu [1 ]
Tang, Yating [1 ]
Huang, Yapeng [1 ]
Chen, Haiyang [1 ]
Wang, Ying [1 ]
Mi, Huaifeng [1 ]
机构：
[1] Nankai Univ, Inst Polymer Chem, Minist Educ, Key Lab Funct Polymer Mat, Tianjin 300071, Peoples R China
来源：
CHEMISTRY LETTERS | 2015年 / 44卷 / 06期
基金：
中国国家自然科学基金;
关键词：
O-H INSERTION; VINYL-POLYMERS; OLIGONUCLEOTIDES; HYBRIDIZATION; CHEMISTRY; ACID;
D O I：
10.1246/cl.150098
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A type of brush-shaped copolymer with natural DNA as the main chain is synthesized. Multiple alkyne groups are introduced onto the phosphate backbone of natural DNA via an O-H insertion reaction, thus rendering the DNA sequence reactive for the subsequent grafting with azide-terminated poly(ethylene glycol) (PEG-N-3) by click reaction. This is the first synthesis of natural DNA as a main chain brush-shaped copolymer. The resulting novel copolymer may have potential for electrochemical DNA biosensors and gene delivery.
引用
收藏
页码：740 / 742
页数：3
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