Harnessing Metabolomics to Advance Epilepsy Research

被引：4
作者：
Eid, Tore [1 ,2 ,3 ,4 ]
机构：
[1] Yale Sch Med, Dept Lab Med, 330 Cedar St,POB 208035, New Haven, CT 06520 USA
[2] Yale Sch Med, Dept Neurosurg, New Haven, CT 06520 USA
[3] Yale Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA
[4] Yale New Haven Hosp, Clin Chem Lab, 20 York St, New Haven, CT 06504 USA
来源：
EPILEPSY CURRENTS | 2022年 / 22卷 / 02期
基金：
美国国家卫生研究院;
关键词：
biomarkers; chromatography; epileptogenesis; mass spectrometry; metabolomics; seizure forecasting; GLUTAMINE-SYNTHETASE; BRAIN; SEIZURE; HIPPOCAMPUS; BLOOD;
D O I：
10.1177/15357597221074518
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Metabolomics is the laboratory analysis and scientific study of the metabolome-that is, the entire collection of small molecule chemicals in an organism. The metabolome represents the functional state of an organism and provides a multifaceted readout of the aggregate activity of endogenous (cellular) and exogenous (environmental) processes. In this review, we discuss how the integrative and dynamic properties of the metabolome create unique opportunities to study complex pathologies that evolve and oscillate over time, like epilepsy. We explain how the scientific progress and clinical applications of metabolomics remain hampered by biological and technical challenges, and we propose best practices to overcome these challenges so that metabolomics can be used in a rigorous and effective manner to further epilepsy research.
引用
收藏
页码：123 / 129
页数：7
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