Intrinsic CO2 Permeability of Cell Membranes and Potential Biological Relevance of CO2 Channels

被引：51

作者：

Boron, Walter F. ^{[1
]}

Endeward, Volker ^{[2
]}

Gros, Gerolf ^{[2
]}

Musa-Aziz, Raif ^{[1
]}

Pohl, Peter ^{[3
]}

机构：

[1] Case Western Reserve Univ, Dept Physiol & Biophys, Cleveland, OH 44122 USA

[2] Hannover Med Sch, Zentrum Physiol, D-30625 Hannover, Germany

[3] Johannes Kepler Univ Linz, Inst Biophys, A-4040 Linz, Austria

来源：

CHEMPHYSCHEM | 2011年 / 12卷 / 05期

关键词：

carbon dioxide; gas permeation; membranes; phospholipids; transport; PLANAR LIPID BILAYERS; CARBON-DIOXIDE PERMEABILITY; RED-BLOOD-CELLS; XENOPUS OOCYTES; WATER CHANNELS; O-18; EXCHANGE; AQUAPORIN; TRANSPORT; AQP1; PERMEATION;

D O I：

10.1002/cphc.201100034

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The past dozen years has seen a series of papers that come to the conclusion that CO2 passes through certain aquaporins and Rhesus proteins. The past three years has seen another series of papers that come to the conclusion that protein channels could not make a meaningful contribution to overall CO2 membrane permeability because of a combination of: 1) a high CO2 permeability of membrane lipids and 2) large unstirred layers, which would render their CO2 resistance much higher than that of a biological membrane. Is this also true for a membrane crowded with proteins? This comment summarizes the current status of the debate. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1017 / 1019

页数：3

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