The role of Fas ligand in immune privilege

被引：214
作者：
Green, DR [1 ]
Ferguson, TA
机构：
[1] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA
[2] Washington Univ, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA
[3] Washington Univ, Dept Pathol & Immunol, St Louis, MO 63110 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 12期
关键词：
D O I：
10.1038/35103104
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Immune privilege is a property of some sites in the body, whereby immune responses are limited or prevented. One explanation that has been proposed for this phenomenon is engagement of the pro-apoptotic molecule Fas by its ligand (FasL), which leads to apoptosis, and consequently limits an inflammatory response. This idea has recently been challenged, and here we review the evidence for and against a role for FasL in immune privilege.
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页码：917 / 924
页数：8
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