Cationic switchable lipids: pH-triggered molecular switch for siRNA delivery

被引：45
作者：
Viricel, W. [1 ]
Poirier, S. [2 ]
Mbarek, A. [1 ]
Derbali, R. M. [1 ]
Mayer, G. [1 ,2 ]
Leblond, J. [1 ]
机构：
[1] Univ Montreal, Fac Pharm, Downtown Stn, POB 6128, Montreal, PQ, Canada
[2] Montreal Heart Inst, Lab Mol Cell Biol, Montreal, PQ H1T 1C8, Canada
来源：
NANOSCALE | 2017年 / 9卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
IN-VIVO; ENDOSOMAL ESCAPE; NONHUMAN-PRIMATES; NANOPARTICLES; CANCER; THERAPEUTICS; POTENCY; SIZE; RNAI; EFFICIENCY;
D O I：
10.1039/c6nr06701h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A pH-sensitive molecular switch able to change its conformation upon protonation at endosomal pH values is embedded into the structure of cationic lipidoid materials, thus conferring endosomal escape properties. Involvement of the conformational switch in the endosomal escape process was confirmed and leading material identified was able to induce efficient gene knockdown both in vitro and in vivo. The lipid nanoparticles reported here are promising for therapeutic applications and this work could serve as a template for future design of stimulus-responsive (ionic, redox, light) molecular switch for drug and gene delivery.
引用
收藏
页码：31 / 36
页数：6
相关论文
共 50 条
[31]   Efficient, pH-Triggered Drug Delivery Using a pH-Responsive DNA-Conjugated Gold Nanoparticle [J].
Song, Lei ;
Ho, Vincent H. B. ;
Chen, Chun ;
Yang, Zhongqiang ;
Liu, Dongsheng ;
Chen, Rongjun ;
Zhou, Dejian .
ADVANCED HEALTHCARE MATERIALS, 2013, 2 (02) :275-280
[32]   A Virus-Mimicking, Endosomolytic Liposomal System for Efficient, pH-Triggered Intracellular Drug Delivery [J].
Chen, Siyuan ;
Chen, Rongjun .
ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (34) :22457-22467
[33]   pH-Triggered Reversible Multiple Protein-Polymer Conjugation Based on Molecular Recognition [J].
Liu, Juan ;
Postupalenko, Viktoriia ;
Duskey, Jason T. ;
Palivan, Cornelia G. ;
Meier, Wolfgang .
JOURNAL OF PHYSICAL CHEMISTRY B, 2015, 119 (36) :12066-12073
[34]   Schiff based injectable hydrogel for in situ pH-triggered delivery of doxorubicin for breast tumor treatment [J].
Shi, Junbin ;
Guobao, Wang ;
Chen, Hongli ;
Zhong, Wen ;
Qiu, Xiaozhong ;
Xing, Malcolm M. Q. .
POLYMER CHEMISTRY, 2014, 5 (21) :6180-6189
[35]   AIEgens-functionalised hydroxyapatite rods for explosive detection in water and pH-triggered drug delivery [J].
Wang, Duo ;
Li, Dongdong .
INORGANIC CHEMISTRY COMMUNICATIONS, 2018, 91 :105-107
[36]   Polymersome nanoreactors with tumor pH-triggered selective membrane permeability for prodrug delivery, activation, and combined oxidation-chemotherapy [J].
Mukerabigwi, Jean Felix ;
Yin, Wei ;
Zha, Zengshi ;
Ke, Wendong ;
Wang, Yuheng ;
Chen, Weijian ;
Japir, Abd Al-Wali Mohammed Mohammed ;
Wang, Yi ;
Ge, Zhishen .
JOURNAL OF CONTROLLED RELEASE, 2019, 303 :209-222
[37]   Molecular dynamics simulation of a cucurbituril based molecular switch triggered by pH changes [J].
Malhis, Lama D. ;
Bodoor, Khaled ;
Assaf, Khaleel I. ;
Al-Sakhen, Nada A. ;
El-Barghouthi, Musa. I. .
COMPUTATIONAL AND THEORETICAL CHEMISTRY, 2015, 1066 :104-112
[38]   Integrated prodrug micelles with two-photon bioimaging and pH-triggered drug delivery for cancer theranostics [J].
Xu, Hong ;
Ma, Boxuan ;
Jiang, Jizhou ;
Xiao, Sutong ;
Peng, Rongrong ;
Zhuang, Weihua ;
Li, Gaocan ;
Wang, Yunbing .
REGENERATIVE BIOMATERIALS, 2020, 7 (02) :171-180
[39]   A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo [J].
Sato, Yusuke ;
Hatakeyama, Hiroto ;
Sakurai, Yu ;
Hyodo, Mamoru ;
Akita, Hidetaka ;
Harashima, Hideyoshi .
JOURNAL OF CONTROLLED RELEASE, 2012, 163 (03) :267-276
[40]   Synthesis of conformation switchable cationic polypeptides based on poly(S-propargyl-cysteine) for use as siRNA delivery [J].
Yi, Ling ;
Wang, Yisi ;
Lin, Guanliang ;
Lin, Danling ;
Chen, Wenliang ;
Huang, Yugang ;
Ye, Guodong .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 101 :758-767
12345