Role of Hydrogen Sulfide in the Regulation of Cell Apoptosis

被引：9

作者：

Ryazantseva, N. V. ^{[1
]}

Novitsky, V. V. ^{[1
]}

Starikova, E. G. ^{[1
]}

Kleptsova, L. A. ^{[1
]}

Jakushina, V. D. ^{[1
]}

Kaigorodova, E. V. ^{[1
]}

机构：

[1] Siberian State Med Univ, Russian Minist Hlth Care & Social Dev, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 151卷 / 06期

关键词：

apoptosis; hydrogen sulfide; caspases; H2S;

D O I：

10.1007/s10517-011-1420-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of a gas transmitter hydrogen sulfide (H(2)S) on the realization of apoptosis in Jurkat cells and mononuclear leukocytes from healthy donors. Treatment with H(2)S donor NaHS was accompanied by a dose-dependent intensification of cell death via apoptosis and necrosis. T-cell leukemia cells were more sensitive to H(2)S than mononuclear leukocytes from healthy donors. H(2)S-induced cell apoptosis was accompanied by activation of caspase-3 and caspase-9.

引用

页码：702 / 704

页数：3

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