Role of Hydrogen Sulfide in the Regulation of Cell Apoptosis

被引：9
|
作者：
Ryazantseva, N. V. [1 ]
Novitsky, V. V. [1 ]
Starikova, E. G. [1 ]
Kleptsova, L. A. [1 ]
Jakushina, V. D. [1 ]
Kaigorodova, E. V. [1 ]
机构：
[1] Siberian State Med Univ, Russian Minist Hlth Care & Social Dev, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 151卷 / 06期
关键词：
apoptosis; hydrogen sulfide; caspases; H2S;
D O I：
10.1007/s10517-011-1420-y
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of a gas transmitter hydrogen sulfide (H(2)S) on the realization of apoptosis in Jurkat cells and mononuclear leukocytes from healthy donors. Treatment with H(2)S donor NaHS was accompanied by a dose-dependent intensification of cell death via apoptosis and necrosis. T-cell leukemia cells were more sensitive to H(2)S than mononuclear leukocytes from healthy donors. H(2)S-induced cell apoptosis was accompanied by activation of caspase-3 and caspase-9.
引用
收藏
页码：702 / 704
页数：3
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