Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells

被引：29

作者：

Altenbuchner, Peter T. ^{[1
]}

Werz, Patrick D. L. ^{[1
]}

Schoeppner, Patricia ^{[2
,3
]}

Adams, Friederike ^{[1
]}

Kronast, Alexander ^{[1
]}

Schwarzenboeck, Christina ^{[1
]}

Poethig, Alexander ^{[4
,5
]}

Jandl, Christian ^{[4
,5
]}

Haslbeck, Martin ^{[2
,3
]}

Rieger, Bernhard ^{[1
]}

机构：

[1] Tech Univ Munich, WACKER Lehrstuhl Makromol Chem, Lichtenbergstr 4, D-85748 Garching, Germany

[2] Tech Univ Munich, CIPSM, Lichtenbergstr 4, D-85748 Garching, Germany

[3] Tech Univ Munich, Lehrstuhl Biotechnol, Lichtenbergstr 4, D-85748 Garching, Germany

[4] Tech Univ Munich, Dept Chem, Ernst Otto Fischer Str 1, D-85748 Garching, Germany

[5] Tech Univ Munich, Catalysis Res Ctr, Ernst Otto Fischer Str 1, D-85748 Garching, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 41期

关键词：

drug delivery; group-transfer polymerization; micelles; stimuli-responsive release; vinylphosphonates; GROUP-TRANSFER POLYMERIZATION; TRIBLOCK COPOLYMERS; METATHESIS POLYMERIZATION; PRECISION POLYMERIZATION; CO-DELIVERY; ABA-TYPE; DOXORUBICIN; MICELLES; BLOCK; POLYMERS;

D O I：

10.1002/chem.201601822

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

C-H bond activation of 2-methoxyethylamino-bis(phenolate)-yttrium catalysts allowed the synthesis of BAB block copolymers comprised of 2-vinylpyridine (2VP; monomerA) and diethylvinylphosphonate (DEVP; monomerB) as the A and B blocks, respectively, by rare-earth-metal-mediated group-transfer polymerization (REM-GTP). The inherent multi-stimuli-responsive character and drug-loading and -release capabilities were observed to be dependent on the chain length and monomer ratios. Cytotoxicity assays revealed the biocompatibility and nontoxic nature of the obtained micelles toward ovarian cancer (HeLa) cells. The BAB block copolymers effectively encapsulated, transported, and released doxorubicin (DOX) within HeLa cells. REM-GTP enables access to previously unattainable vinylphosphonate copolymer structures, and thereby unlocks their full potential as nanocarriers for stimuli-responsive drug delivery in HeLa cells. The self-evident consequence is the application of these new micelles as potent drug-delivery vehicles with reduced side effects in future cancer therapies.

引用

页码：14576 / 14584

页数：9

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