A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

被引：24

作者：

Ayaz, Muhammad ^{[1
]}

Dietrich, Justin ^{[1
]}

Hulme, Christopher ^{[1
,2
]}

机构：

[1] Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA

[2] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 38期

关键词：

Petasis reaction; Multicomponent reaction; Quinoxaline; Intramolecular cyclization; Microwave; BIOLOGICAL EVALUATION; DERIVATIVES; ACID; ANTIBACTERIAL; ANTIFUNGAL; INHIBITORS; DISCOVERY; DESIGN;

D O I：

10.1016/j.tetlet.2011.06.115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：4821 / 4823

页数：3

共 33 条

[1] Synthesis of certain substituted quinoxalines as antimicrobial agents (part II) [J].