Towards a dengue vaccine: Progress to date and remaining challenges

被引:37
作者
Guy, Bruno [1 ]
Almond, Jeffrey W. [1 ]
机构
[1] Sanofi Pasteur, F-69280 Marcy Letoile, France
关键词
dengue; vaccine; clinical trials; antibodies; cellular immunity; vaccine safety;
D O I
10.1016/j.cimid.2007.07.011
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The increased incidence and extended geographical reach of Dengue virus over the past two decades have made the development of an effective vaccine an international urgency. Various strategies are being pursued, including live, vectored and killed/recombinant preparations. For all approaches, the challenge is to induce a broad durable immune response against all four serotypes of Dengue virus simultaneously whilst avoiding the possible exacerbation of risk of developing the severe forms of disease through incomplete or modified responses. This review presents the current state of knowledge and discusses the challenges of further clinical development. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:239 / 252
页数:14
相关论文
共 46 条
  • [1] Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok
    Adams, B.
    Holmes, E. C.
    Zhang, C.
    Mammen, M. P., Jr.
    Nimmannitya, S.
    Kalayanarooj, S.
    Boots, M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) : 14234 - 14239
  • [2] Almond Jeffrey, 2002, Vaccine, V20, P3043, DOI 10.1016/S0264-410X(02)00246-3
  • [3] Tetravalent neutralizing antibody response against four dengue serotypes by a single chimeric dengue envelope antigen
    Apt, D
    Raviprakash, K
    Brinkman, A
    Semyonov, A
    Yang, SM
    Skinner, C
    Diehl, L
    Lyons, R
    Porter, K
    Punnonen, J
    [J]. VACCINE, 2006, 24 (03) : 335 - 344
  • [4] Development of a live attenuated dengue virus vaccine using reverse genetics
    Blaney, JE
    Durbin, AP
    Murphy, BR
    Whitehead, SS
    [J]. VIRAL IMMUNOLOGY, 2006, 19 (01) : 10 - 32
  • [5] Short report: Immune response and occurrence of dengue infection in thai children three to eight years after vaccination with live attenuated tetravalent dengue vaccine
    Chanthavanich, Pornthep
    Luxemburger, Christine
    Sirivichayakul, Chukiat
    Lapphra, Keswadee
    Pengsaa, Krisana
    Yoksan, Sutee
    Sabchareon, Arunee
    Lang, Jean
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2006, 75 (01) : 26 - 28
  • [6] Innate immune responses in human dendritic cells upon infection by chimeric yellow-fever dengue vaccine serotypes 1-4
    Deauvieau, Florence
    Sanchez, Violette
    Balas, Claire
    Kennel, Audrey
    De Montfort, Aymeric
    Lang, Jean
    Guy, Bruno
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 76 (01) : 144 - 154
  • [7] The WHO dengue classification and case definitions: time for a reassessment
    Deen, Jacqueline L.
    Harris, Eva
    Wills, Bridget
    Balmaseda, Angel
    Hammond, Samantha Nadia
    Rocha, Crisanta
    Dung, Nguyen Minh
    Hung, Nguyen Thanh
    Hien, Tran Tinh
    Farrar, Jeremy J.
    [J]. LANCET, 2006, 368 (9530) : 170 - 173
  • [8] Modification of dengue virus strains by passage in primary dog kidney cells: Preparation of candidate vaccines and immunization of monkeys
    Eckels, KH
    Dubois, DR
    Putnak, R
    Vaughn, DW
    Innis, BL
    Henchal, EA
    Hoke, CH
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2003, 69 (06) : 12 - 16
  • [9] Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand
    Endy, TP
    Nisalak, A
    Chunsuttitwat, S
    Vaughn, DW
    Green, S
    Ennis, FA
    Rothman, AL
    Libraty, DH
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2004, 189 (06) : 990 - 1000
  • [10] Immunopathological mechanisms in dengue and dengue hemorrhagic fever
    Green, Sharone
    Rothman, Alan
    [J]. CURRENT OPINION IN INFECTIOUS DISEASES, 2006, 19 (05) : 429 - 436