The increased incidence and extended geographical reach of Dengue virus over the past two decades have made the development of an effective vaccine an international urgency. Various strategies are being pursued, including live, vectored and killed/recombinant preparations. For all approaches, the challenge is to induce a broad durable immune response against all four serotypes of Dengue virus simultaneously whilst avoiding the possible exacerbation of risk of developing the severe forms of disease through incomplete or modified responses. This review presents the current state of knowledge and discusses the challenges of further clinical development. (C) 2007 Elsevier Ltd. All rights reserved.
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Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USAWalter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Eckels, KH
Dubois, DR
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机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Dubois, DR
Putnak, R
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机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Putnak, R
Vaughn, DW
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机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Vaughn, DW
Innis, BL
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机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Innis, BL
Henchal, EA
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机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Henchal, EA
Hoke, CH
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机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
机构:
Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USAWalter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Eckels, KH
Dubois, DR
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h-index: 0
机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Dubois, DR
Putnak, R
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h-index: 0
机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Putnak, R
Vaughn, DW
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h-index: 0
机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Vaughn, DW
Innis, BL
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h-index: 0
机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Innis, BL
Henchal, EA
论文数: 0引用数: 0
h-index: 0
机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA
Henchal, EA
Hoke, CH
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h-index: 0
机构:Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA