Cytokines for monitoring anti-tuberculous therapy: A systematic review

被引：45

作者：

Clifford, Vanessa ^{[1
,2
]}

Zufferey, Christel ^{[1
,2
]}

Street, Alan ^{[3
]}

Denholm, Justin ^{[3
]}

Tebruegge, Marc ^{[1
,2
,4
,5
,6
]}

Curtis, Nigel ^{[1
,2
]}

机构：

[1] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia

[2] Royal Childrens Hosp Melbourne, Murdoch Childrens Res Inst, Parkville, Vic, Australia

[3] Royal Melbourne Hosp, Victorian Infect Dis Unit, Parkville, Vic 3050, Australia

[4] Univ Southampton, Fac Med, Acad Unit Clin & Expt Med, Southampton SO9 5NH, Hants, England

[5] Univ Southampton, Resp Biomed Res Unit, Southampton SO9 5NH, Hants, England

[6] Univ Southampton, Inst Life Sci, Southampton SO9 5NH, Hants, England

来源：

TUBERCULOSIS | 2015年 / 95卷 / 03期

关键词：

Mycobacterium tuberculosis; Tuberculosis; Immunomodulation; Diagnosis; Antibiotics; Cytokines; TUMOR-NECROSIS-FACTOR; ACTIVE PULMONARY TUBERCULOSIS; INTERFERON-GAMMA LEVELS; T-CELL RESPONSES; MYCOBACTERIUM-TUBERCULOSIS; IFN-GAMMA; IMMUNE-RESPONSES; DISEASE-ACTIVITY; FACTOR-ALPHA; WHOLE-BLOOD;

D O I：

10.1016/j.tube.2015.01.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability to monitor response to therapy for tuberculosis (TB) and confirm adequate treatment would be a major advance. The low reversion rate of interferon-gamma based assays means that they are unlikely to be useful for monitoring therapy. Several exploratory studies have evaluated the diagnostic potential of cytokine biomarkers other than interferon-gamma for monitoring anti-tuberculous therapy. A systematic review of these studies was performed to identify the most promising candidate biomarkers. TNF-alpha, IL-2, IL-6, IL-10 and IL-12 were the most extensively investigated cytokines. There was significant heterogeneity between studies in relation to study design and laboratory methodology, complicating direct comparisons. There was marked variation between studies in the observed changes during treatment for many of the biomarkers. Further longitudinal studies in sufficiently large patient cohorts with rigorous methodology are needed to determine the true potential of individual cytokine biomarkers, or combinations, for monitoring TB treatment. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.

引用

页码：217 / 228

页数：12

共 65 条

[1] Reversion of the ELISPOT test after treatment in Gambian tuberculosis cases [J].