Specificity and Breadth of the Neutralizing Antibody Response to a Live-Attenuated Tetravalent Dengue Vaccine

被引：11
作者：
DeMaso, Christina R. [1 ]
Karwal, Lovkesh [1 ]
Zahralban-Steele, Melissa [1 ]
Dominguez, David [1 ]
Springer, Zhang-Li [1 ]
Kaiser, Maima [1 ]
Palani, Sunil [1 ]
Rindfleisch, Tim [1 ]
Bohning, Kelly [1 ]
Hather, Greg [1 ]
Das, Subash [1 ]
Sharma, Mayuri [1 ]
Dean, Hansi J. [1 ]
机构：
[1] Takeda Pharmaceut USA, Vaccines Business Unit, Cambridge, MA USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2022年 / 226卷 / 11期
关键词：
dengue vaccine; dengue virus; neutralizing antibody response; TAK-003; type-specific; IMMUNOGENICITY; INFECTIONS; SAFETY; ADULTS;
D O I：
10.1093/infdis/jiac272
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background An effective dengue vaccine should ideally induce broadly neutralizing antibody (nAb) responses against all 4 dengue virus (DENV) serotypes. Methods We characterized the specificity and breadth of the nAb response to TAK-003, a live-attenuated tetravalent dengue vaccine, in serum samples from phase 2 and 3 clinical trials. Results Microneutralization tests using postvaccination serum showed comparable neutralization against diverse DENV-1-4 genotypes. Reporter virus particle neutralization assays after depletion of anti-DENV-2 nAbs demonstrated that the nAb response to DENV-1, -3, and -4 comprises both type-specific (TS) and cross-reactive (CR) nAbs. Conclusions Therefore, TAK-003 induces broad tetravalent TS and CR nAb responses. We characterized the specificity and breadth of neutralizing antibody (nAb) response to a live-attenuated tetravalent dengue vaccine candidate and found that the nAb response comprised both type-specific and cross-reactive nAbs, with comparable neutralization of diverse dengue genotypes.
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页码：1959 / 1963
页数：5
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