Amyloid β protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease

被引：205
作者：
Mehta, PD
Pirttila, T
Patrick, BA
Barshatzky, M
Mehta, SP
机构：
[1] New York State Inst Basic Res Dev Disabil, Dept Immunol, Staten Isl, NY 10314 USA
[2] Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland
来源：
NEUROSCIENCE LETTERS | 2001年 / 304卷 / 1-2期
关键词：
Alzheimer disease; amyloid beta protein; alpha; 1-antichymotrypsin; apolipoprotein E; enzyme linked immunosorbent assay;
D O I：
10.1016/S0304-3940(01)01754-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We quantitated amyloid beta proteins 1-40 (A beta 40) and 1-42 (A beta 42), and alpha1-antichymotrypsin (ACT) in matched cerebrospinal fluid (CSF) and plasma of 50 patients with probable Alzheimer disease, and analyzed the relationships with age, sex, Mini-Mental State Examination (MMSE), and apolipoprotein E phenotype. There was no relation between CSF A beta 40 and A beta 42 levels with those of plasma. CSF and plasma A beta 40 and A beta 42 levels showed no association with age, sex, and MMSE score. There was a significant correlation between CSF ACT and plasma ACT levels. The data suggest that plasma ACT crosses the blood-brain barrier. However, a lack of correlation between CSF A beta 40 and A beta 42 levels with those of plasma suggests that A beta in CSF and plasma originates from different sources. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：102 / 106
页数：5
相关论文
共 21 条
[1]   IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].
ABRAHAM, CR ;
SELKOE, DJ ;
POTTER, H .
CELL, 1988, 52 (04) :487-501
[2]   Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid [J].
Calhoun, ME ;
Burgermeister, P ;
Phinney, AL ;
Stalder, M ;
Tolnay, M ;
Wiederhold, KH ;
Abramowski, D ;
Sturchler-Pierrat, C ;
Sommer, B ;
Staufenbiel, M ;
Jucker, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (24) :14088-14093
[3]   PLATELETS ARE THE PRIMARY SOURCE OF AMYLOID BETA-PEPTIDE IN HUMAN BLOOD [J].
CHEN, M ;
INESTROSA, NC ;
ROSS, GS ;
FERNANDEZ, HL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 213 (01) :96-103
[4]   High cerebrospinal fluid tau and low amyloid β42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype [J].
Galasko, D ;
Chang, L ;
Motter, R ;
Clark, CM ;
Kaye, J ;
Knopman, D ;
Thomas, R ;
Kholodenko, D ;
Schenk, D ;
Lieberburg, I ;
Miller, B ;
Green, R ;
Basherad, R ;
Kertiles, L ;
Boss, MA ;
Seubert, P .
ARCHIVES OF NEUROLOGY, 1998, 55 (07) :937-945
[5]  
GhersiEgea JF, 1996, J NEUROCHEM, V67, P880
[6]   AMYLOID-BETA PROTEIN (A-BETA) IN ALZHEIMERS-DISEASE BRAIN - BIOCHEMICAL AND IMMUNOCYTOCHEMICAL ANALYSIS WITH ANTIBODIES SPECIFIC FOR FORMS ENDING AT A-BETA-40 OR A-BETA-42(43) [J].
GRAVINA, SA ;
HO, LB ;
ECKMAN, CB ;
LONG, KE ;
OTVOS, L ;
YOUNKIN, LH ;
SUZUKI, N ;
YOUNKIN, SG .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (13) :7013-7016
[7]  
KATAOKA S, 1994, CLIN CHEM, V40, P11
[8]   PASSAGE OF HUMAN AMYLOID BETA-PROTEIN-1-40 ACROSS THE MURINE BLOOD-BRAIN-BARRIER [J].
MANESS, LM ;
BANKS, WA ;
PODLISNY, MB ;
SELKOE, DJ ;
KASTIN, AJ .
LIFE SCIENCES, 1994, 55 (21) :1643-1650
[9]   ALPHA-1-ANTICHYMOTRYPSIN AS A POSSIBLE BIOCHEMICAL MARKER FOR ALZHEIMER-TYPE DEMENTIA [J].
MATSUBARA, E ;
HIRAI, S ;
AMARI, M ;
SHOJI, M ;
YAMAGUCHI, H ;
OKAMOTO, K ;
ISHIGURO, K ;
HARIGAYA, Y ;
WAKABAYASHI, K .
ANNALS OF NEUROLOGY, 1990, 28 (04) :561-567
[10]  
Mayeux R, 1999, ANN NEUROL, V46, P412, DOI 10.1002/1531-8249(199909)46:3<412::AID-ANA19>3.0.CO
123