A convenient solid-phase method for the synthesis of novel oligonucleotide-folate conjugates

被引：1
|
作者：
Kazanova, Eugenia V. [2 ,3 ]
Zubin, Eugeny M. [2 ,3 ]
Kachalova, Anna V. [2 ,3 ]
Volkov, Eugeny M. [2 ,3 ]
Oretskaya, Tatiana S. [2 ,3 ]
Stetsenko, Dmitry A. [1 ]
Gottikh, Marina B. [2 ,3 ]
机构：
[1] Univ Surrey, Grad Biomed & Mol Sci, Surrey GU2 7XH, England
[2] Moscow MV Lomonosov State Univ, Dept Chem, Moscow, Russia
[3] Moscow MV Lomonosov State Univ, AN Belozersky Inst Phys Chem Biol, Moscow, Russia
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2007年 / 26卷 / 10-12期
关键词：
oligonucleotide; folic acid; conjugate; solid support;
D O I：
10.1080/15257770701530459
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We describe the Preparation of two batches of a polymer support for the incorporation of folic acid into oligonucleotides. The method permits the regioselective attachment of a target nucleic acid sequence through its 3'-end to either the alpha- or gamma-carboxyl group of L-glutamic acid, respectively. The supports have been tested in solid-phase synthesis of oligonucleotide-folate conjugates for cell delivery studies.
引用
收藏
页码：1273 / 1276
页数：4
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