A convenient solid-phase method for the synthesis of novel oligonucleotide-folate conjugates

被引：1

作者：

Kazanova, Eugenia V. ^{[2
,3
]}

Zubin, Eugeny M. ^{[2
,3
]}

Kachalova, Anna V. ^{[2
,3
]}

Volkov, Eugeny M. ^{[2
,3
]}

Oretskaya, Tatiana S. ^{[2
,3
]}

Stetsenko, Dmitry A. ^{[1
]}

Gottikh, Marina B. ^{[2
,3
]}

机构：

[1] Univ Surrey, Grad Biomed & Mol Sci, Surrey GU2 7XH, England

[2] Moscow MV Lomonosov State Univ, Dept Chem, Moscow, Russia

[3] Moscow MV Lomonosov State Univ, AN Belozersky Inst Phys Chem Biol, Moscow, Russia

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2007年 / 26卷 / 10-12期

关键词：

oligonucleotide; folic acid; conjugate; solid support;

D O I：

10.1080/15257770701530459

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the Preparation of two batches of a polymer support for the incorporation of folic acid into oligonucleotides. The method permits the regioselective attachment of a target nucleic acid sequence through its 3'-end to either the alpha- or gamma-carboxyl group of L-glutamic acid, respectively. The supports have been tested in solid-phase synthesis of oligonucleotide-folate conjugates for cell delivery studies.

引用

页码：1273 / 1276

页数：4

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