Temperature-Responsive Polymer Brushes Switching from Bactericidal to Cell-Repellent

被引：132
作者：
Laloyaux, Xavier [1 ]
Fautre, Emilie [1 ]
Blin, Thomas [2 ,3 ]
Purohit, Viswas [2 ,3 ]
Leprince, Jerome [4 ]
Jouenne, Thierry [2 ,3 ]
Jonas, Alain M. [1 ]
Glinel, Karine [1 ]
机构：
[1] Catholic Univ Louvain, Inst Condensed Matter & Nanosci Bio & Soft Matter, B-1348 Louvain, Belgium
[2] Univ Rouen, Lab Polymeres, UMR 6270, F-76821 Mont St Aignan, France
[3] Univ Rouen, FR 3038, F-76821 Mont St Aignan, France
[4] Univ Rouen, INSERM, U982, Lab Differenciat & Commun Neuronale & Neuroendocr, F-76821 Mont St Aignan, France
来源：
ADVANCED MATERIALS | 2010年 / 22卷 / 44期
关键词：
ANTIMICROBIAL PEPTIDES; POLY(N-ISOPROPYLACRYLAMIDE); ANTIBACTERIAL; SURFACE; CYTOTOXICITY; METHACRYLATE; TRANSITIONS;
D O I：
10.1002/adma.201002538
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The composition of temperature-responsive copolymer brushes based on oligo(ethylene glycol) methacrylates is tuned to obtain a collapse temperature of approximate to 35 degrees C. The chains are grafted by antibacterial magainin I peptide, whose activity is tested at different temperatures against various bacteria. The brushes switch from bactericidal to cell-repellent below and slightly above 35 degrees C, respectively, due to the progressive vertical collapse of the brush.
引用
收藏
页码：5024 / +
页数：6
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