Recombinant influenza virus expressing a fusion protein neutralizing epitope of respiratory syncytial virus (RSV) confers protection without vaccine-enhanced RSV disease
被引:15
作者:
Lee, Yu-Na
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机构:
Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USAGeorgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
Lee, Yu-Na
[1
]
Hwang, Hye Suk
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机构:
Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USAGeorgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
Hwang, Hye Suk
[1
]
Kim, Min-Chul
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机构:
Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
Anim & Plant Quarantine Agcy, Anyang, Gyeonggi Do, South KoreaGeorgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
Kim, Min-Chul
[1
,2
]
Lee, Young-Tae
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机构:
Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USAGeorgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
Lee, Young-Tae
[1
]
Lee, Jong Seok
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机构:
Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USAGeorgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
Lee, Jong Seok
[1
]
Moore, Martin L.
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h-index: 0
机构:
Emory Univ, Dept Pediat, Atlanta, GA 30322 USA
Childrens Healthcare Atlanta, Atlanta, GA USAGeorgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
Moore, Martin L.
[3
,4
]
Kang, Sang-Moo
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Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USAGeorgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
Kang, Sang-Moo
[1
]
机构:
[1] Georgia State Univ, Inst Biomed Sci, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA
[2] Anim & Plant Quarantine Agcy, Anyang, Gyeonggi Do, South Korea
[3] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA
Respiratory syncytial virus (RSV) is the leading cause of viral bronchiolitis in both children and the elderly. There is no vaccine available for the prevention of RSV infection. Here, we generated recombinant influenza virus (PR8/RSV.HA-F) expressing an RSV F243-294 neutralizing epitope in the hemagglutinin (HA) as a chimeric protein. Neutralizing antibodies specific for both RSV and influenza virus were induced by a single intranasal immunization of mice with PR8/RSV.HA-F. Mice that were immunized with PR8/RSV.HA-F were protected against RSV infection comparable with live RSV as evidenced by significant reduction of RSV lung viral loads, as well as the absence of lung eosinophilia and RSV-specific cellular immune responses. In contrast, formalin-inactivated RSV-immunized mice showed severe disease and high cellular immune responses in lungs after RSV infection. These findings support a concept that recombinant influenza virus carrying the RSV F243-294 neutralizing epitope can be developed as a promising RSV vaccine candidate which induces protective neutralizing antibodies but avoids lung immunopathology. (C) 2014 Elsevier B.V. All rights reserved.
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Ningxia Med Univ, Dept Pathogen Biol & Med Immunol, Sch Basic Med Sci, Yinchuan 750004, Peoples R China
302 Mil Hosp, Ctr Clin Lab, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Bian, Chengrong
Liu, Shuzhen
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Food & Drug Control, Beijing 100050, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Liu, Shuzhen
Liu, Na
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Ningxia Med Univ, Dept Pathogen Biol & Med Immunol, Sch Basic Med Sci, Yinchuan 750004, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Liu, Na
Zhang, Guangzhou
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h-index: 0
机构:
Acad Mil & Med Sci, Lab Anim Ctr, Beijing 100071, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Zhang, Guangzhou
Xing, Li
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Xing, Li
Song, Yingwei
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Peoples Liberat Army Gen Hosp, Dept Blood Transfus, Beijing 100853, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Song, Yingwei
Duan, Yueqiang
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h-index: 0
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Duan, Yueqiang
Gu, Hongjing
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h-index: 0
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Gu, Hongjing
Zhou, Ya
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h-index: 0
机构:
Ningxia Med Univ, Dept Pathogen Biol & Med Immunol, Sch Basic Med Sci, Yinchuan 750004, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Zhou, Ya
Zhang, Peirui
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h-index: 0
机构:
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Zhang, Peirui
Li, Zhiwei
论文数: 0引用数: 0
h-index: 0
机构:
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Li, Zhiwei
Zhang, Keming
论文数: 0引用数: 0
h-index: 0
机构:
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Zhang, Keming
Wang, Zhaohai
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h-index: 0
机构:
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Wang, Zhaohai
Zhang, Shaogeng
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h-index: 0
机构:
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Zhang, Shaogeng
Wang, Xiliang
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Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Wang, Xiliang
Yang, Penghui
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机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
机构:
Hosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, SpainHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Carbonell-Estrany, Xavier
Simoes, Eric A. F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Sch Med, Dept Pediat, Denver, CO USA
Childrens Hosp, Div Infect Dis, Denver, CO 80218 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Simoes, Eric A. F.
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Dagan, Ron
Hall, Caroline B.
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h-index: 0
机构:
Univ Rochester, Med Ctr, Dept Pediat, Rochester, NY 14642 USA
Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Hall, Caroline B.
Harris, Brian
论文数: 0引用数: 0
h-index: 0
机构:
Medimmune Inc, Gaithersburg, MD 20878 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Harris, Brian
Hultquist, Micki
论文数: 0引用数: 0
h-index: 0
机构:
Medimmune Inc, Gaithersburg, MD 20878 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Hultquist, Micki
Connor, Edward M.
论文数: 0引用数: 0
h-index: 0
机构:
Medimmune Inc, Gaithersburg, MD 20878 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Connor, Edward M.
Losonsky, Genevieve A.
论文数: 0引用数: 0
h-index: 0
机构:
Medimmune Inc, Gaithersburg, MD 20878 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
机构:
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Castilow, Elaine M.
Varga, Steven M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
机构:
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Castilow, Elaine M.
Olson, Matthew R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Olson, Matthew R.
Meyerholz, David K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Meyerholz, David K.
Vargal, Steven M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Ningxia Med Univ, Dept Pathogen Biol & Med Immunol, Sch Basic Med Sci, Yinchuan 750004, Peoples R China
302 Mil Hosp, Ctr Clin Lab, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Bian, Chengrong
Liu, Shuzhen
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Food & Drug Control, Beijing 100050, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Liu, Shuzhen
Liu, Na
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Ningxia Med Univ, Dept Pathogen Biol & Med Immunol, Sch Basic Med Sci, Yinchuan 750004, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Liu, Na
Zhang, Guangzhou
论文数: 0引用数: 0
h-index: 0
机构:
Acad Mil & Med Sci, Lab Anim Ctr, Beijing 100071, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Zhang, Guangzhou
Xing, Li
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Xing, Li
Song, Yingwei
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Peoples Liberat Army Gen Hosp, Dept Blood Transfus, Beijing 100853, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Song, Yingwei
Duan, Yueqiang
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Duan, Yueqiang
Gu, Hongjing
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Gu, Hongjing
Zhou, Ya
论文数: 0引用数: 0
h-index: 0
机构:
Ningxia Med Univ, Dept Pathogen Biol & Med Immunol, Sch Basic Med Sci, Yinchuan 750004, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Zhou, Ya
Zhang, Peirui
论文数: 0引用数: 0
h-index: 0
机构:
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Zhang, Peirui
Li, Zhiwei
论文数: 0引用数: 0
h-index: 0
机构:
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Li, Zhiwei
Zhang, Keming
论文数: 0引用数: 0
h-index: 0
机构:
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Zhang, Keming
Wang, Zhaohai
论文数: 0引用数: 0
h-index: 0
机构:
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Wang, Zhaohai
Zhang, Shaogeng
论文数: 0引用数: 0
h-index: 0
机构:
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Zhang, Shaogeng
Wang, Xiliang
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Wang, Xiliang
Yang, Penghui
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
302 Mil Hosp, Dept Hepatobiliary, Beijing 100039, Peoples R ChinaBeijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
机构:
Hosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, SpainHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Carbonell-Estrany, Xavier
Simoes, Eric A. F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Sch Med, Dept Pediat, Denver, CO USA
Childrens Hosp, Div Infect Dis, Denver, CO 80218 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Simoes, Eric A. F.
论文数: 引用数:
h-index:
机构:
Dagan, Ron
Hall, Caroline B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rochester, Med Ctr, Dept Pediat, Rochester, NY 14642 USA
Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14642 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Hall, Caroline B.
Harris, Brian
论文数: 0引用数: 0
h-index: 0
机构:
Medimmune Inc, Gaithersburg, MD 20878 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Harris, Brian
Hultquist, Micki
论文数: 0引用数: 0
h-index: 0
机构:
Medimmune Inc, Gaithersburg, MD 20878 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Hultquist, Micki
Connor, Edward M.
论文数: 0引用数: 0
h-index: 0
机构:
Medimmune Inc, Gaithersburg, MD 20878 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
Connor, Edward M.
Losonsky, Genevieve A.
论文数: 0引用数: 0
h-index: 0
机构:
Medimmune Inc, Gaithersburg, MD 20878 USAHosp St Joan de Deu, Hosp Clin, Serv Neonatol, Agrupacio Saniteria Clin, Barcelona 08028, Spain
机构:
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Castilow, Elaine M.
Varga, Steven M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
机构:
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Castilow, Elaine M.
Olson, Matthew R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Olson, Matthew R.
Meyerholz, David K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Pathol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Meyerholz, David K.
Vargal, Steven M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA
Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USAUniv Iowa, Interdisciplinary Grad Program Immunol, Iowa City, IA 52242 USA