The Emerging Role of Electronic Medical Records in Pharmacogenomics

被引：119

作者：

Wilke, R. A. ^{[1
]}

Xu, H. ^{[2
]}

Denny, J. C. ^{[2
]}

Roden, D. M. ^{[1
]}

Krauss, R. M. ^{[3
]}

McCarty, C. A. ^{[4
]}

Davis, R. L. ^{[5
]}

Skaar, T. ^{[6
]}

Lamba, J. ^{[7
]}

Savova, G. ^{[8
,9
,10
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Div Clin Pharmacol, Nashville, TN 37235 USA

[2] Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA

[3] Childrens Hosp, Oakland Res Inst, Dept Atherosclerosis Res, Ctr Nutr & Metab, Oakland, CA 94609 USA

[4] Marshfield Clin Fdn Med Res & Educ, Ctr Human Genet, Marshfield, WI 54449 USA

[5] Kaiser Permanente, Ctr Hlth Res SE, Atlanta, GA USA

[6] Indiana Univ Sch Med, Dept Med, Div Clin Pharmacol, Indianapolis, IN USA

[7] Univ Minnesota, Dept Expt & Clin Pharmacol, Minneapolis, MN USA

[8] Mayo Clin, Dept Biomed Informat, Rochester, MN USA

[9] Childrens Hosp, Childrens Hosp Informat Program, Boston, MA 02115 USA

[10] Harvard Univ, Sch Med, Dept Biomed Informat, Boston, MA USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2011年 / 89卷 / 03期

关键词：

HEALTH RECORDS; AMBULATORY-CARE; ATORVASTATIN; SYSTEM; RISK; POLYMORPHISM; POPULATION; GENOTYPE; GENOMICS; STATINS;

D O I：

10.1038/clpt.2010.260

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Health-care information technology and genotyping technology are both advancing rapidly, creating new opportunities for medical and scientific discovery. The convergence of these two technologies is now facilitating genetic association studies of unprecedented size within the context of routine clinical care. As a result, the medical community will soon be presented with a number of novel opportunities to bring functional genomics to the bedside in the area of pharmacotherapy. By linking biological material to comprehensive medical records, large multi-institutional biobanks are now poised to advance the field of pharmacogenomics through three distinct mechanisms: (i) retrospective assessment of previously known findings in a clinical practice-based setting, (ii) discovery of new associations in huge observational cohorts, and (iii) prospective application in a setting capable of providing real-time decision support. This review explores each of these translational mechanisms within a historical framework.

引用

页码：379 / 386

页数：8

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