Behavioral Changes as the Earliest Clinical Manifestation of Progressive Supranuclear Palsy

被引：19

作者：

Han, Hyun Jeong ^{[1
]}

Kim, Hyeyun ^{[1
]}

Park, Jong-Ho ^{[1
]}

Shin, Hyung-Woo ^{[1
]}

Kim, Go Un ^{[1
]}

Kim, Dong Sun ^{[1
]}

Lee, Eun Ja ^{[2
]}

Oh, Hwa Eun ^{[3
]}

Park, Seung-Hye ^{[4
]}

Kim, Yun Jung ^{[5
]}

机构：

[1] Kwandong Univ, Coll Med, Myongji Hosp, Dept Neurol, Goyang 412270, South Korea

[2] Kwandong Univ, Coll Med, Myongji Hosp, Dept Radiol, Goyang 412270, South Korea

[3] Kwandong Univ, Coll Med, Myongji Hosp, Dept Pathol, Goyang 412270, South Korea

[4] Seoul Natl Univ Hosp, Dept Pathol, Seoul 110744, South Korea

[5] Hallym Univ, Ilsong Inst Life Sci, Dept Neurol, Pongchon, South Korea

来源：

JOURNAL OF CLINICAL NEUROLOGY | 2010年 / 6卷 / 03期

关键词：

frontotemporal dementia; parkinsonism; progressive supranuclear palsy; RICHARDSON-OLSZEWSKI-SYNDROME; PSP;

D O I：

10.3988/jcn.2010.6.3.148

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background The clinical and pathological heterogeneity of progressive supranuclear palsy (PSP) is well established. Even with a well-defined clinical phenotype and a thorough laboratory workup, PSP can be misdiagnosed, especially in its early stages. Case Report A 52-year-old woman, who we initially diagnosed with a behavioral variant of frontotemporal dementia developed parkinsonian features, which then progressed to gait instability and gaze abnormality. Conclusions We report herein a pathologically confirmed case of PSP presenting with behavioral changes including agitation and irritability, which eventually led to the cardinal symptoms of progressive supranuclear palsy. J Clin Neurol 2010;6:148-151

引用

页码：148 / 151

页数：4

共 12 条

[1]

[Anonymous], 1998, NEUROLOGY, DOI [DOI 10.1212/WNL.48.5_SUPPL_6.10S, DOI 10.1212/WNL.51.1.48]

[2]

Choi SH., 2001, J. Korean Neurol. Assoc., V19, P585

[3] FRONTAL-LOBE FUNCTION IN PROGRESSIVE SUPRANUCLEAR PALSY [J].

GRAFMAN, J ;

LITVAN, I ;

GOMEZ, C ;

CHASE, TN .

ARCHIVES OF NEUROLOGY, 1990, 47 (05) :553-558

[4] Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP [J].

Josephs, KA ;

Petersen, RC ;

Knopman, DS ;

Boeve, BF ;

Whitwell, JL ;

Duffy, JR ;

Parisi, JE ;

Dickson, DW .

NEUROLOGY, 2006, 66 (01) :41-48

[5]

Kang Y., 1997, J Korean Neurol Assoc, V15, P300, DOI DOI 10.1371/JOURNAL.PONE.0099638

[6] Neuropsychiatric aspects of progressive supranuclear palsy [J].

Litvan, I ;

Mega, MS ;

Cummings, JL ;

Fairbanks, L .

NEUROLOGY, 1996, 47 (05) :1184-1189

[7] Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): Report of the NINDS-SPSP International Workshop [J].

Litvan, I ;

Agid, Y ;

Calne, D ;

Campbell, G ;

Dubois, B ;

Duvoisin, RC ;

Goetz, CG ;

Golbe, LI ;

Grafman, J ;

Growdon, JH ;

Hallett, M ;

Jankovic, J ;

Quinn, NP ;

Tolosa, E ;

Zee, DS ;

Chase, TN ;

FitzGibbon, EJ ;

Hall, Z ;

Juncos, J ;

Nelson, KB ;

Oliver, E ;

Pramstaller, P ;

Reich, SG ;

Verny, M .

NEUROLOGY, 1996, 47 (01) :1-9

[8] Neurodegenerative disorders mimicking progressive supranuclear palsy: a report of three cases [J].

Murphy, MA ;

Friedman, JH ;

Tetrud, JW ;

Factor, SA .

JOURNAL OF CLINICAL NEUROSCIENCE, 2005, 12 (08) :941-945

[9] Progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): A short historical review [J].

Pearce, J. M. S. .

NEUROLOGIST, 2007, 13 (05) :302-304

[10] PROGRESSIVE SUPRANUCLEAR PALSY MISDIAGNOSED AS SCHIZOPHRENIA [J].

TRZEPACZ, PT ;

MURCKO, AC ;

GILLESPIE, MP .

JOURNAL OF NERVOUS AND MENTAL DISEASE, 1985, 173 (06) :377-378

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