Purification and in vitro activity of an antimicrobial peptide from skin of Rana temporaria chensinensis, David

被引：2

作者：

Zhou Jie

Meng Qing-fan

Xu Xue-song

Tian Xiao-le

Jiang Fu-jia

Li Qing-shan

Teng Li-rong ^{[1
]}

机构：

[1] Jilin Univ, Coll Life Sci, Changchun 130012, Peoples R China

[2] Jilin Univ, China Japan Union Hosp, Dept Lab, Changchun 130033, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2007年 / 23卷 / 04期

关键词：

antimicrobial peptides; multi-drug resistant; amphibian skin; TOAD BOMBINA-MAXIMA; ANTIBACTERIAL PEPTIDES; PIG INTESTINE; SECRETIONS; FROG; RESISTANCE; IMMUNITY; CLONING;

D O I：

10.1016/S1005-9040(07)60094-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, an antimicrobial component(RTCI) was purified from the skin of Rana temporaria chensinensis, David. Antimicrobial activities of RTCI against clinical multi-drug resistant bacterial strains, including Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureaus, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis, and Proteus mirabilis were measured in vitro by means of minimal inhibitory concentration and time-kill studies. The results indicate that RTCI could inhibit the growth of these bacteria at a proper concentration and suggest that RTCI shows a better antimicrobial activity to Gram-negative bacterial strains than to Gram-positive bacterial strains.

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页码：433 / 436

页数：4

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