Activatable Rare Earth Near-Infrared-II Fluorescence Ratiometric Nanoprobes

被引:79
作者
Sun, Ziqiang [1 ,2 ,3 ]
Huang, Haoying [2 ,3 ]
Zhang, Rong [2 ,3 ,4 ]
Yang, Xiaohu [2 ,3 ]
Yang, Hongchao [2 ,3 ]
Li, Chunyan [2 ,3 ]
Zhang, Yejun [2 ,3 ]
Wang, Qiangbin [1 ,2 ,3 ,4 ]
机构
[1] Univ Sci & Technol China, Sch Nanotech & Nanobion, Hefei 230026, Peoples R China
[2] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Div Nanobiomed, CAS Key Lab Nanobio Interface, Suzhou 215123, Peoples R China
[3] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, I Lab, Suzhou 215123, Peoples R China
[4] ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
NIR-II fluorescence; lanthanide dopant; energy migration; ratiometric imaging; peroxynitrite detection; QUANTUM DOTS; RHEUMATOID-ARTHRITIS; ELEMENTAL MIGRATION; SHELL THICKNESS; NANOPARTICLES; DEPENDENCE; SURFACE; PROBE; OH;
D O I
10.1021/acs.nanolett.1c01962
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Rational design of efficient lanthanide-doped downshifting nanoparticles (DSNPs) has attracted tremendous attention. However, energy loss was inevitable in the multiple Ln(3+) doping systems owing to complex energy migration processes. Here, an efficient NaErF4@NaYF4@NaYF4:10%Nd@NaYF4 DSNP was tactfully designed, in which a buffer layer of NaYF4 was modulated to restrict the interionic energy migration between Er3+ and Nd3+; meanwhile, the surface defects were passivated by an outermost layer of NaYF4. Therefore, the asprepared DSNPs exhibited two intensive near-infrared-II fluorescence emissions of 1525 nm from Er3+ and 1060 nm from doped Nd3+ under 808 nm excitation. Further, a novel ratiometric nanoprobe NaErF4@ NaYF4@NaYF4:10%Nd@NaYF4@A1094 was fabricated by coupling an organic dye of A1094 onto the DSNP surface to quench the 1060 nm emission by the efficient Forster resonance energy transfer, while emission at 1525 nm retained. Thereafter, these activatable ratiometric nanoprobes were used for rapid and sensitive detection of peroxynitrite (ONOO-) in vivo.
引用
收藏
页码:6576 / 6583
页数:8
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