Cavitation as a plausible driving force for the prebiotic formation of N9 purine nucleosides

被引：11

作者：

Patehebieke, Yeersen ^{[1
]}

Zhao, Ze-Run ^{[1
]}

Wang, Su ^{[1
]}

Xu, Hao-Xing ^{[1
]}

Chen, Qian-Qian ^{[1
]}

Wang, Xiao ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210023, Jiangsu, Peoples R China

来源：

CELL REPORTS PHYSICAL SCIENCE | 2021年 / 2卷 / 03期

基金：

中国国家自然科学基金;

关键词：

RADICALS; PYRIMIDINE; CHEMISTRY; ORIGIN; WATER; ACID; SONOCHEMISTRY; NUCLEOBASES; NUCLEOTIDE; EARTH;

D O I：

10.1016/j.xcrp.2021.100375

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

For the RNA world hypothesis, the direct condensation between nucle-obase and ribose to afford canonical nucleoside has been a formidable challenge in terms of regioselectivity. In this report, we demonstrate that cavitation, a frequently occurring energy-intensive phenomenon upon the collapse of bubbles, could be a plausible driving force to form the purine nucleosides directly from nucleobase and ribose with the desired regioselectivity. Under cavitation, the overall yield of N9 nucleosides increases compared with non-cavitation conditions, whereas the amount of the undesired ribosylamino isomers decreases. Plausible geochemical scenarios on primordial Earth are proposed that could facilitate enrichment of the desired N9 nucleosides. Under salt-free dry-wet conditions, much improved yield (7.2%) and selectivity (N9/ribosylamino = 0.45) of the N9 isomers are achieved compared with the classical routes.

引用

页数：13

共 48 条

[1]

Airapetian VS, 2016, NAT GEOSCI, V9, P452, DOI [10.1038/ngeo2719, 10.1038/NGEO2719]

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