3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis

被引：44

作者：

Shcherbakova, I ^{[1
]}

Balandrin, MF ^{[1
]}

Fox, J ^{[1
]}

Ghatak, A ^{[1
]}

Heaton, WL ^{[1
]}

Conklin, RL ^{[1
]}

机构：

[1] NPS Pharmaceut Inc, Drug Discovery, Salt Lake City, UT 84108 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 06期

关键词：

calcium receptor antagonists; calcilytics; osteoporosis; 3H-quinazolin-4-ones;

D O I：

10.1016/j.bmcl.2005.01.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-activity relationship studies, focused on identification of the active pharmacophore fragments in a single high-throughput screening calcilytic bit, resulted in the discovery of potent calcium receptor antagonists, substituted 3H-quinazolin-4-ones. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1557 / 1560

页数：4

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