Catastrophic Endgames: Emerging Mechanisms of Telomere-Driven Genomic Instability

被引：27

作者：

Cleal, Kez ^{[1
]}

Baird, Duncan M. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Med, Div Canc & Genet, Heath Pk, Cardiff CF14 4XN, Wales

来源：

TRENDS IN GENETICS | 2020年 / 36卷 / 05期

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; FUSION-BRIDGE EVENTS; DNA-DAMAGE; CHROMOSOME INSTABILITY; MUTATIONAL PROCESSES; CHROMOTHRIPSIS; LENGTH; REARRANGEMENTS; DYSFUNCTION; SENESCENCE;

D O I：

10.1016/j.tig.2020.02.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

When cells progress to malignancy, they must overcome a final telomere-mediated proliferative lifespan barrier called replicative crisis. Crisis is characterized by extensive telomere fusion that drives widespread genomic instability, mitotic arrest, hyperactivation of autophagy, and cell death. Recently, it has become apparent that that the resolution of dicentric chromosomes, which arise from telomere fusions during crisis, can initiate a sequence of events that leads to chromothripsis, a form of extreme genomic catastrophe. Chromothripsis is characterized by localized genomic regions containing tens to thousands of rearrangements and it is becoming increasingly apparent that chromothripsis occurs widely across tumor types and has a clinical impact. Here we discuss how telomere dysfunction can initiate genomic complexity and the emerging mechanisms of chromothripsis.

引用

页码：347 / 359

页数：13

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