Genetic/Bio Design Automation for (Re-) Engineering Biological Systems

被引：0

作者：

Hassoun, Soha ^{[1
]}

机构：

[1] Tufts Univ, Dept Comp Sci, Medford, MA 02155 USA

来源：

DESIGN, AUTOMATION & TEST IN EUROPE (DATE 2012) | 2012年

基金：

美国国家科学基金会;

关键词：

SYNTHETIC BIOLOGY; OPTIMIZATION; PATHWAYS; CONSEQUENCES; ALGORITHM; CELLS;

D O I：

暂无

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Constructing biological circuits in a bottom-up modular fashion using design methodologies similar to those used in electronics has gained tremendous attention in the past decade. The end goal, however, is engineering biological systems and not only individual components in the context of pursuing applications useful in improving human health or enhancing the environment. This article reviews the basics of biological system design rooted in Metabolic Engineering and Systems Biology and outlines current system-level modeling, analysis, optimization, and synthesis with emphasis on some current bottlenecks in establishing more rigorous design tools and methodologies for engineering biological systems.

引用

页码：242 / 247

页数：6

共 45 条

[41] Programming cells by multiplex genome engineering and accelerated evolution [J].