Genetic/Bio Design Automation for (Re-) Engineering Biological Systems

被引：0
作者：
Hassoun, Soha [1 ]
机构：
[1] Tufts Univ, Dept Comp Sci, Medford, MA 02155 USA
来源：
DESIGN, AUTOMATION & TEST IN EUROPE (DATE 2012) | 2012年
基金：
美国国家科学基金会;
关键词：
SYNTHETIC BIOLOGY; OPTIMIZATION; PATHWAYS; CONSEQUENCES; ALGORITHM; CELLS;
D O I：
暂无
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
Constructing biological circuits in a bottom-up modular fashion using design methodologies similar to those used in electronics has gained tremendous attention in the past decade. The end goal, however, is engineering biological systems and not only individual components in the context of pursuing applications useful in improving human health or enhancing the environment. This article reviews the basics of biological system design rooted in Metabolic Engineering and Systems Biology and outlines current system-level modeling, analysis, optimization, and synthesis with emphasis on some current bottlenecks in establishing more rigorous design tools and methodologies for engineering biological systems.
引用
收藏
页码：242 / 247
页数：6
相关论文
共 45 条
  • [1] BglBricks: A flexible standard for biological part assembly
    Anderson J.C.
    Dueber J.E.
    Leguia M.
    Wu G.C.
    Arkin A.P.
    Keasling J.D.
    [J]. Journal of Biological Engineering, 4 (1)
  • [2] Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene
    Anthony, Jennifer R.
    Anthony, Larry C.
    Nowroozi, Farnaz
    Kwon, Gina
    Newman, Jack D.
    Keasling, Jay D.
    [J]. METABOLIC ENGINEERING, 2009, 11 (01) : 13 - 19
  • [3] Fast, cheap and somewhat in control
    Arkin, Adam P.
    Fletcher, Daniel A.
    [J]. GENOME BIOLOGY, 2006, 7 (08)
  • [4] Energy balance for analysis of complex metabolic networks
    Beard, DA
    Liang, SC
    Qian, H
    [J]. BIOPHYSICAL JOURNAL, 2002, 83 (01) : 79 - 86
  • [5] Boyle P. M., 2011, METABOLIC ENG
  • [6] From DNA to Targeted Therapeutics: Bringing Synthetic Biology to the Clinic
    Chen, Yvonne Y.
    Smolke, Christina D.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (106)
  • [7] Critical perspective on the consequences of the limited availability of kinetic data in metabolic dynamic modelling
    Costa, R. S.
    Machado, D.
    Rocha, I.
    Ferreira, E. C.
    [J]. IET SYSTEMS BIOLOGY, 2011, 5 (03) : 157 - 163
  • [8] The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli
    Feist, Adam M.
    Palsson, Bernhard O.
    [J]. NATURE BIOTECHNOLOGY, 2008, 26 (06) : 659 - 667
  • [9] Fell D., 1997, Understanding the Control of Metabolism
  • [10] Thermodynamics-based metabolic flux analysis
    Henry, Christopher S.
    Broadbelt, Linda J.
    Hatzimanikatis, Vassily
    [J]. BIOPHYSICAL JOURNAL, 2007, 92 (05) : 1792 - 1805
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