Airway Metabolic Anomalies in Adolescents with Bronchopulmonary Dysplasia: New Insights from the Metabolomic Approach

被引：30

作者：

Carraro, Silvia ^{[1
]}

Giordano, Giuseppe ^{[1
]}

Pirillo, Paola ^{[1
]}

Maretti, Michela ^{[1
]}

Reniero, Fabiano ^{[2
]}

Cogo, Paola E. ^{[3
]}

Perilongo, Giorgio ^{[1
]}

Stocchero, Matteo ^{[4
]}

Baraldi, Eugenio ^{[1
]}

机构：

[1] Univ Padua, Womens & Childrens Hlth Dept, I-35128 Padua, Italy

[2] European Commiss, Joint Res Ctr, Inst Hlth & Consumer Protect IHCP, Syst Toxicol Unit ST, Ispra, VA, Italy

[3] Bambino Gesu Pediat Hosp, Rome, Italy

[4] S IN Soluz Informat, Vicenza, Italy

来源：

JOURNAL OF PEDIATRICS | 2015年 / 166卷 / 02期

关键词：

EXHALED BREATH CONDENSATE; PULMONARY SURFACTANT; LUNG-FUNCTION; RESPIRATORY HEALTH; OXIDATIVE STRESS; CYSTIC-FIBROSIS; SYSTEMS BIOLOGY; CHILDREN; DISEASE; ASTHMA;

D O I：

10.1016/j.jpeds.2014.08.049

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objectives To assess a group of adolescents with bronchopulmonary dysplasia (BPD) from a biochemical-metabolic standpoint, applying the metabolomic approach to studying their exhaled breath condensate (EBC). Study design Twenty adolescents with BPD (mean age 14.8 years) and 15 healthy controls (mean age 15.2 years) were recruited for EBC collection, exhaled nitric oxide measurement, and spirometry. The EBC samples were analyzed using a metabolomic approach based on mass spectrometry. The obtained spectra were analyzed using multivariate statistical analysis tools. Results A reliable Orthogonal Projections to Latent Structures-Discriminant Analysis model showed a clear discrimination between cases of BPD and healthy controls (R-2 = 0.95 and Q(2) = 0.92). The search for putative biomarkers identified an altered complex lipid profile in the adolescents with BPD. Conclusions The metabolomic analysis of EBC distinguishes cases of BPD from healthy individuals, suggesting that the lung of survivors of BPD is characterized by long-term metabolic abnormalities. The search for putative biomarkers indicated a possible role of an altered surfactant composition, which may persist far beyond infancy.

引用

页码：234 / +

页数：7

共 40 条

[1] Impaired Vascular Endothelial Growth Factor Signaling in the Pathogenesis of Neonatal Pulmonary Vascular Disease [J].