1,8-Naphthalimide modified [12]aneN3 compounds as selective and sensitive probes for Cu2+ ions and ATP in aqueous solution and living cells

被引：44

作者：

Gao, Yong-Guang ^{[1
]}

Tang, Quan ^{[1
]}

Shi, You-Di ^{[1
]}

Zhang, Ying ^{[1
]}

Lu, Zhong-Lin ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Xinjiekouwai St 19, Beijing 100875, Peoples R China

来源：

TALANTA | 2016年 / 152卷

关键词：

Naphthalimide; 12]aneN(3); Cu2+; ATP; Phosphates; DNA CONDENSATION AGENTS; ON FLUORESCENT SENSOR; NONVIRAL GENE VECTORS; BIFUNCTIONAL MOLECULES; PERYLENE DIIMIDE; NUCLEOSIDE POLYPHOSPHATES; PYROPHOSPHATE ANION; COLORIMETRIC PROBE; ELECTRON-TRANSFER; RECENT PROGRESS;

D O I：

10.1016/j.talanta.2016.02.040

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new fluorescent probe I featuring one 1,8-naphthalimide and two [12]aneN(3) units was synthesized. In the presence of Cu2+ ions, the fluorescence emission of 1 was quenched by a factor of 127-fold and no interference by other metal ions was observed under physiological conditions. By means of titration and a Job's plot it was established that 1 forms a complex with Cu2+ ions in a 1:2 ratio. The fluorescence of the 1-Cu2+ complex was recovered by the addition of Adenosine-5'-triphosphate (ATP) in aqueous solution. Due to its low cytotoxicity, good water solubility, and high sensitivity, probe 1 was successfully applied in the sequential recognition of Cu2+ and ATP in aqueous solution and HeLa cells. The highly selective and sensitive ability of 1-Cu2+ complex to detect ATP even enables its bio-analytical applications in real-time imaging in living cells. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：438 / 446

页数：9

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