1,8-Naphthalimide modified [12]aneN3 compounds as selective and sensitive probes for Cu2+ ions and ATP in aqueous solution and living cells

被引：44

作者：

Gao, Yong-Guang ^{[1
]}

Tang, Quan ^{[1
]}

Shi, You-Di ^{[1
]}

Zhang, Ying ^{[1
]}

Lu, Zhong-Lin ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Xinjiekouwai St 19, Beijing 100875, Peoples R China

来源：

TALANTA | 2016年 / 152卷

关键词：

Naphthalimide; 12]aneN(3); Cu2+; ATP; Phosphates; DNA CONDENSATION AGENTS; ON FLUORESCENT SENSOR; NONVIRAL GENE VECTORS; BIFUNCTIONAL MOLECULES; PERYLENE DIIMIDE; NUCLEOSIDE POLYPHOSPHATES; PYROPHOSPHATE ANION; COLORIMETRIC PROBE; ELECTRON-TRANSFER; RECENT PROGRESS;

D O I：

10.1016/j.talanta.2016.02.040

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new fluorescent probe I featuring one 1,8-naphthalimide and two [12]aneN(3) units was synthesized. In the presence of Cu2+ ions, the fluorescence emission of 1 was quenched by a factor of 127-fold and no interference by other metal ions was observed under physiological conditions. By means of titration and a Job's plot it was established that 1 forms a complex with Cu2+ ions in a 1:2 ratio. The fluorescence of the 1-Cu2+ complex was recovered by the addition of Adenosine-5'-triphosphate (ATP) in aqueous solution. Due to its low cytotoxicity, good water solubility, and high sensitivity, probe 1 was successfully applied in the sequential recognition of Cu2+ and ATP in aqueous solution and HeLa cells. The highly selective and sensitive ability of 1-Cu2+ complex to detect ATP even enables its bio-analytical applications in real-time imaging in living cells. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：438 / 446

页数：9

共 82 条

[1] Selective colorimetric and fluorometric sensing of Cu(II) by iminocoumarin derivative in aqueous buffer [J].

Ahamed, B. Nisar ;

Ghosh, Pradyut .

DALTON TRANSACTIONS, 2011, 40 (24) :6411-6419

[2] Triple channel responsive Cu2+ probe [J].

Algi, Melek Pamuk ;

Oztas, Zahide ;

Algi, Fatih .

CHEMICAL COMMUNICATIONS, 2012, 48 (82) :10219-10221

[3] Infrared Absorption Detection of Metal Ion-Deoxyguanosine Monophosphate Binding: Experimental and Theoretical Study [J].

Andrushchenko, Valery ;

Bour, Petr .

JOURNAL OF PHYSICAL CHEMISTRY B, 2009, 113 (01) :283-291

[4] ATP-sensitive K+ channels and insulin secretion:: their role in health and disease [J].

Ashcroft, FM ;

Gribble, FM .

DIABETOLOGIA, 1999, 42 (08) :903-919

[5] Luminescent probes for the bioimaging of small anionic species in vitro and in vivo [J].

Ashton, Trent D. ;

Jolliffe, Katrina A. ;

Pfeffer, Frederick M. .

CHEMICAL SOCIETY REVIEWS, 2015, 44 (14) :4547-4595

[6] 2,2′-Biimidazole-Based Conjugated Polymers as a Novel Fluorescent Sensing Platform for Pyrophosphate Anion [J].

Bao, Yinyin ;

Wang, Hu ;

Li, Qianbiao ;

Liu, Bin ;

Li, Qing ;

Bai, Wei ;

Jin, Bangkun ;

Bai, Ruke .

MACROMOLECULES, 2012, 45 (08) :3394-3401

[7] LUMINESCENT IMMOBILIZED ENZYME TEST SYSTEMS FOR INORGANIC PYROPHOSPHATE - ASSAYS USING FIREFLY LUCIFERASE AND NICOTINAMIDE-MONONUCLEOTIDE ADENYLYL TRANSFERASE OR ADENOSINE-5'-TRIPHOSPHATE SULFURYLASE [J].

BARSHOP, BA ;

ADAMSON, DT ;

VELLOM, DC ;

ROSEN, F ;

EPSTEIN, BL ;

SEEGMILLER, JE .

ANALYTICAL BIOCHEMISTRY, 1991, 197 (01) :266-272

[8] ANTIBIOTICS AS TOOLS FOR METABOLIC STUDIES .3. EFFECTS OF OLIGOMYCIN AND AUROVERTIN ON SWELLING AND CONTRACTION PROCESSES OF MITOCHONDRIA [J].

CONNELLY, JL ;

LARDY, HA .

BIOCHEMISTRY, 1964, 3 (12) :1969-&

[9] Mammalian TOR: A homeostatic ATP sensor [J].

Dennis, PB ;

Jaeschke, A ;

Saitoh, M ;

Fowler, B ;

Kozma, SC ;

Thomas, G .

SCIENCE, 2001, 294 (5544) :1102-1105

[10] Colorimetric and fluorescent anion sensors: an overview of recent developments in the use of 1,8-naphthalimide-based chemosensors [J].

Duke, Rebecca M. ;

Veale, Emma B. ;

Pfeffer, Frederick M. ;

Kruger, Paul E. ;

Gunnlaugsson, Thorfinnur .

CHEMICAL SOCIETY REVIEWS, 2010, 39 (10) :3936-3953

← 1 2 3 4 5 6 7 8 9 →