Synthetic Development and Assessment of Antioxidant Activity of Imino[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile and Its Derivatives

被引：3

作者：

Wadwale, N. B. ^{[1
]}

Prasad, D. ^{[2
]}

Jadhav, A. H. ^{[2
]}

Karad, A. R. ^{[3
]}

Khansole, G. S. ^{[4
]}

Choudhare, S. S. ^{[5
]}

Navhate, S., V ^{[6
]}

Bhosale, V. N. ^{[6
]}

机构：

[1] MSG Coll Malegaon, Dept Chem, PG Res Ctr, Malegaon 423105, Maharashtra, India

[2] JAIN Univ, Ctr Nano & Mat Sci, Bangalore 562112, Karnataka, India

[3] MGM Ahmedpur, Dept Chem, Ahmdepur 413515, Maharashtra, India

[4] DABN Coll, Dept Chem, Chikhali 415408, Maharashtra, India

[5] SD Coll, Dept Chem, Soegaon 431120, Maharashtra, India

[6] Yeshwant Mahavidvalay Nanded, Dept Chem, PG Res Ctr, Nanded 431602, Maharashtra, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 57卷 / 12期

关键词：

multicomponent reactions (MCR); 1; 2; 4-triazole; 4]triazolo[1; 5-a]pyrimidine; 2-[bis(methyl-sulfanyl)methylidene]malononitrile; antioxidant activity; MULTICOMPONENT REACTIONS; PHARMACOLOGICAL EVALUATION; ALZHEIMERS-DISEASE; SOLVENT-FREE; AGENTS; ACID; HETEROCYCLES; DESIGN;

D O I：

10.1134/S1070428021120204

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 2-[bis(methylsulfanyl)methylidene]malononitrile with 1H-1,2,4-triazol-3-amine in N,N-dimethylformamide in the presence of anhydrous potassium carbonate led to the formation of 7-imino-5-(methylsulfanyl)-1,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile. The latter was then reacted with some nitrogen and carbon nucleophiles such as substituted anilines and active methylene compounds to afford the corresponding 5-substituted derivatives. The structure of the synthesized compounds was confirmed by IR, NMR, and mass spectra and elemental analyses. Furthermore, their potential as antioxidant agents was evaluated using DPPH and hydroxyl radical scavenging assays.

引用

页码：2031 / 2038

页数：8

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