Advances in Research on the circRNA-miRNA-mRNA Network in Coronary Heart Disease Treated with Traditional Chinese Medicine

被引：24

作者：

Lin, Fei ^{[1
]}

Chen, Heng-Wen ^{[2
]}

Zhao, Guo-An ^{[1
]}

Li, Yan ^{[1
]}

He, Xuan-Hui ^{[2
]}

Liang, Wan-Qian ^{[1
]}

Shi, Zhuo-Lin ^{[1
]}

Sun, Si-Yu ^{[1
]}

Tian, Pan-Pan ^{[2
]}

Huang, Ming-Yan ^{[2
]}

Liu, Chao ^{[2
]}

机构：

[1] Xinxiang Med Univ, Dept Cardiol, Affiliated Hosp 1, Xinxiang 453100, Henan, Peoples R China

[2] China Acad Chinese Med Sci, Dept Cardiol, Guanganmen Hosp, Beijing 100053, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2020年 / 2020卷

关键词：

CIRCULAR RNA; MYOCARDIAL-INFARCTION; UP-REGULATION; HYPERTROPHY; EXPRESSION; APOPTOSIS; PROTECTS; FIBROSIS; PATHWAY; MIR-21;

D O I：

10.1155/2020/8048691

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

There has been an increase in morbidity and mortality related to coronary heart disease (CHD) in China in recent years. Numerous clinical experiences and studies have shown that traditional Chinese medicine (TCM) plays an important role in the prevention, treatment, and prognosis of CHD. However, the mechanism of TCM in the treatment of CHD has not yet been elucidated. The circRNA-miRNA-mRNA network consists of miRNA that is competitively bound by circRNA, and miRNA regulates the transcription level of mRNA. Through literature review, we found that the circRNA-miRNA-mRNA network acts to contribute to certain effects to CHD such as myocardial hypertrophy, myocardial fibrosis, and heart failure. TCM contains constituents that act against CHD by antiatherosclerosis and apoptosis inhibition action, cardiac and cardiomyocyte protection, and these components also promote cell growth and protection of the vascular system by regulating miRNAs. Therefore, we consider that the circRNA-miRNA-mRNA network may be a new regulatory mechanism for the effective treatment of CHD by TCM.

引用

页数：10

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