Duloxetine-induced rapid eye movement sleep behavior disorder: a case report

被引：13
作者：
Tan, Lu [1 ]
Zhou, Junying [1 ]
Yang, Linghui [1 ]
Ren, Rong [1 ]
Zhang, Ye [1 ]
Li, Taomei [1 ]
Tang, Xiangdong [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Sleep Med Ctr, Lab Anaesthesia & Crit Care Med,Translat Neurosci, Chengdu, Sichuan, Peoples R China
来源：
BMC PSYCHIATRY | 2017年 / 17卷
基金：
中国国家自然科学基金;
关键词：
Duloxetine; Rapid eye movement sleep behavior disorder; Polysomnography; REM-SLEEP; MUSCLE TONE; ANTIDEPRESSANTS; ATONIA; DEPRESSION;
D O I：
10.1186/s12888-017-1535-4
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Background: Tricyclic antidepressants and selective serotonin reuptake inhibitors have been reported to induce the symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) or to exacerbate REM sleep without atonia. With this case report, we found an association between typical RBD and duloxetine, a serotonin-noradrenaline reuptake inhibitor. Case presentation: We present a case of a 62-year-old woman who experienced enactment behaviors with violent dreams that were associated with increased tonic or phasic chin electromyography activity during REM sleep after treated with duloxetine. RBD symptoms were gradually reduced and completely ceased after discontinuation of duloxetine for 37 days. Conclusion: The current case appears to be the first observation of duloxetine-induced RBD. We describe features of RBD induced by duloxetine that are similar and different from that induced by tricyclic antidepressants and selective serotonin reuptake inhibitors.
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页数：5
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