Predominance of SARS-CoV-2 P.1 (Gamma) lineage inducing the recent COVID-19 wave in southern Brazil and the finding of an additional S: D614A mutation

被引：10

作者：

Demoliner, Meriane ^{[1
]}

Silva, Mariana Soares da ^{[1
]}

Gularte, Juliana Schons ^{[1
]}

Hansen, Alana Witt ^{[1
]}

Almeida, Paula Rodrigues de ^{[1
]}

Weber, Matheus Nunes ^{[1
]}

Heldt, Fagner Henrique ^{[1
]}

Silveira, Flavio ^{[1
]}

Filippi, Micheli ^{[1
]}

Pereira, Vyctoria Malayhka de Abreu Goes ^{[1
]}

Silva, Francini Pereira da ^{[1
]}

Mallmann, Larissa ^{[1
]}

Fink, Pietra ^{[1
]}

Valim, Andreia Rosane de Moura ^{[2
]}

Possuelo, Lia Gonsalves ^{[2
]}

Fleck, Juliane Deise ^{[1
]}

Spilki, Fernando Rosado ^{[1
]}

机构：

[1] Univ Feevale, Lab Microbiol Mol, ERS 239,2755, BR-93352000 Novo Hamburgo, RS, Brazil

[2] Univ Santa Cruz do Sul, Santa Cruz Do Sul, RS, Brazil

来源：

INFECTION GENETICS AND EVOLUTION | 2021年 / 96卷

关键词：

Health crisis; COVID-19; B; 1; 25; P; 2; lineage; Gamma lineage;

D O I：

10.1016/j.meegid.2021.105134

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Recently, the highest wave of SARS-CoV-2 epidemic occurred since the beginning of the pandemic in Brazil was registered in Rio Grande do Sul (RS) State, Southern Brazil, considering the number of cases, deaths and hospitalization per day caused by COVID-19. In this study we described which lineages were circulating in the first quarter of 2021 in Southern Brazil to better understand the viral factors involved in the health crisis caused by SARS-CoV-2 in the region, searching also for possible additional SARS-CoV-2 sequence mutations. A total of 70 positive SARS-CoV-2 samples collected between January 28th, 2021 until April 23rd, 2021, were selected to sequencing. Whole genome sequencing of 70 SARS-CoV-2 samples showed a predominance of Gamma lineage (67%, 47/70), followed by P.2 lineage (27%, 19/70) and B.1.1.28 (6%, 4/70). Two Gamma lineage consensus sequences presented a new S:D614A mutation. Newly mutations could be emerging due the quick SARS-CoV-2 spreading. Thus, the greater understanding about immune protection and variants vigilance is essential to the better management of the health SARS-CoV-2 crisis.

引用

页数：6

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