A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China

被引：100

作者：

Han, Zongxi ^{[1
]}

Sun, Chuyang ^{[1
]}

Yan, Baolong ^{[1
]}

Zhang, Xiaonan ^{[1
]}

Wang, Yu ^{[1
]}

Li, Chengren ^{[1
]}

Zhang, Qingxia ^{[1
]}

Ma, Yazhen ^{[1
]}

Shao, Yuhao ^{[1
]}

Liu, Qiaoran ^{[1
]}

Kong, Xiangang ^{[1
]}

Liu, Shengwang ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Div Avian Infect Dis, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Peoples R China

来源：

INFECTION GENETICS AND EVOLUTION | 2011年 / 11卷 / 01期

关键词：

Molecular epidemiology; Avian infectious bronchitis coronavirus; Genotype; VIRUS-STRAINS; SPIKE GLYCOPROTEIN; QX-STRAIN; S1; GENE; CHICKENS; EVOLUTION; PATHOGENICITY; GENOTYPE; SEQUENCE; SEROTYPE;

D O I：

10.1016/j.meegid.2010.09.002

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A comprehensive study of the epidemiology and pathogenicity of infectious bronchitis virus (IBV) in China was carried out by molecular characterization of the 51 gene from 46 isolates obtained for this study and 174 reference strains isolated over a 15-year period. Nine types were found according to sequence analysis and phylogenetic study of the Si gene. The co-circulation of multiple IBV types and the ongoing emergence of IBV variants are the epidemiological challenges in China. Factors contributing to the continual emergence include mutations, insertions and deletions in the Si protein genes; recombination between local IBV strains circulating in chicken flocks in China; and recombination between local strains and vaccine strains. Vaccination-challenge analysis between circulating field strains and Mass-type H120 vaccine indicated the need to develop new vaccines from local IBV strains. These results also emphasize the importance of continued IBV surveillance in China. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：190 / 200

页数：11

共 54 条

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