Suppression of A549 lung cancer cell migration by precursor let-7g microRNA

被引：17

作者：

Park, Sungjin ^{[1
]}

Minai-Tehrani, Arash ^{[1
]}

Xu, Cheng-Xiong ^{[1
]}

Chang, Seung-Hee ^{[1
]}

Woo, Min-Ah ^{[1
,2
]}

Noh, Mi-Suk ^{[1
,2
]}

Lee, Eun-Sun ^{[1
]}

Lim, Hwang-Tae ^{[1
,2
]}

An, Gil-Hwan ^{[3
]}

Lee, Kee-Ho ^{[4
]}

Sung, Ha-Jung ^{[5
]}

Beck, George R., Jr. ^{[6
]}

Cho, Myung-Haing ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Vet Med, Toxicol Lab, Seoul 151742, South Korea

[2] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Nano Fus Technol, Seoul 151742, South Korea

[3] Chungnam Natl Univ, Dept Food Sci & Technol, Coll Agr & Life Sci, Taejon, South Korea

[4] Korea Inst Radiol & Med Sci, Mol Oncol Lab, Seoul, South Korea

[5] Hoseo Univ, Inst Fus Technol, Chungnam, South Korea

[6] Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA USA

来源：

MOLECULAR MEDICINE REPORTS | 2010年 / 3卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

let-7g; microRNA; lung cancer cell migration; GROUP-A PROTEINS; HEPATOCELLULAR-CARCINOMA; SELF-RENEWAL; EXPRESSION; HMGA2; TARGETS; FAMILY; P53; OVEREXPRESSION; PROLIFERATION;

D O I：

10.3892/mmr.2010.373

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Let-7g miRNAs, short non-coding RNAs approximately 21 nucleotides long, repress protein translation by binding to the 3'UTR of target mRNAs. Aberrant expression of let-7g is associated with the poor prognosis of lung cancer patients. Compared to normal lung cells, let-7g expression is absent in non-small cell lung cancer (NSCLC) cells. Furthermore. K-Ras and HMGA2 are well known as targets of let-7g. In this study, we evaluated the potential role of precursor (pre)-let-7g in lung cancer cell metastasis, focusing on the two targets of let-7g, HMGA2 and K-Ras. We found that pre-let-7g inhibited the migration of A549 lung cancer cells through HMGA2-mediated E2F1 down-regulation. Thus, our results suggest that pre-let-7g could be used as a suitable target for the suppression of lung cancer cell migration.

引用

页码：1007 / 1013

页数：7

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