Actin nucleation: bacteria get in-spired

被引：14

作者：

Quinlan, Margot E. ^{[1
]}

Kerkhoff, Eugen ^{[2
]}

机构：

[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94107 USA

[2] Univ Regensburg, Bayer Genomforschungsnetzwerk BayGene, Inst Funkt Genom, D-93053 Regensburg, Germany

来源：

NATURE CELL BIOLOGY | 2008年 / 10卷 / 01期

关键词：

D O I：

10.1038/ncb0108-13

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Spir proteins nucleate actin polymerization by assembling a linear actin oligomer along a cluster of four actin-binding WH2 domains, and this process is enhanced by formins of the Cappuccino family. The discovery of Spir-like proteins in bacteria indicates that pathogens have adopted this mechanism to manipulate the host actin cytoskeleton.

引用

页码：13 / 15

页数：4

共 16 条

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